2018 is the 147th year after the founding of the City of Birmingham.
- February 1: Amtrak began service at the Birmingham Intermodal Facility.
- March 7: The 2018 Huffman High School shooting took place.
- January 2: HealthSouth changed its name to Encompass Health.
- February 1: Avadian Credit Union acquired EBSCO Federal Credit Union.
- McLeod Software moved to Building 100 at the Meadow Brook Corporate Park.
- Main Street Inc. acquired Check Printers Inc. of Dallas, Texas.
- Hospicelink merged with StateServ of Tempe, Arizona.
- February: Diversified Gas & Oil acquired natural gas assets in the Appalachian Basin from Alliance Petroleum and CNX Resources for $180 million.
- J. & M. Convenience Store in Enon Ridge rebranded as 3rd Street Market.
- April: Frontier Airlines began offering service to Birmingham-Shuttlesworth International Airport.
- January 4: Farm Bowl & Juice Co. opened at 1920 29th Avenue South
- January 14: Stephen Gregory: A Men's Concept barber shop opened at Pickwick Plaza
- January: Freddy's Wine Bar in the Highland Towers apartments
- January 26: Wild Things at 2815B 18th Street South Homewood
- February: Brennan's Irish Pub in Five Points South
- February: Pizzeria GM on Oak Grove Road in West Homewood
- February: Lucky Cat Rolled Creams opened at 2908 18th Street South Homewood
- February: D's Tamales opened in Pickwick Plaza in Five Points South
- Caveat Coffee opened in Homewood.
- June: BrickTop's restaurant
- January: Alabama's last K Mart location, in Albertville, Marshall County, closed.
- January: Dorm Decor was acquired by Magnussen Home of New Hamburg, Ontario.
- January: Rowe's Service Station closed.
- January: Schaeffer Eye Center was acquired by My Eye Doctor of Vienna, Virginia.
- January 26: The Sam's Club at 3900 Grants Mill Road closed.
- Infinity Property & Casualty was acquired by Kemper Corp. of Chicago, Illinois.
- January 3: Doug Jones was sworn into the U. S. Senate.
- January 9: The 2018 Alabama legislative session began.
- January 15: Mayor Randall Woodfin delivered his first "State of the Community " address.
- June 5: 2018 primary elections were held statewide.
- July 17: 2018 primary runoff elections were held statewide.
- November 6: The statewide 2018 general election was held.
- January 8: The 2017 Alabama Crimson Tide football team beat the Georgia Bulldogs 26-23 in overtime of the College Football Playoff National Championship at Mercedes-Benz Stadium in Atlanta, Georgia.
- March 17: Field #2 at Luman Harris Park in Gardendale was renamed Steve Ridener Field in memory of Steve Ridener.
- Al Denson retired as president and CEO of Birmingham-Shuttlesworth International Airport.
- January 16: Glenn Murdock resigned from the Alabama Supreme Court.
- January 2: Rick Hall, record producer
- January 4: Bill Bolen, news anchor
- January 13: Brad Watkins, architectural salvage dealer
- January 13: Maurice Branscomb, Episcopal priest
- January 16: George Bandy, State Representative District 83
- January 23: Wyatt Walker, Civil Rights Movement leader
- January 31: Todd Cargo, hair stylist and salon owner
- February 1: Dennis Edwards, soul/R&B vocalist
- February 13: Berry Perry, peanut vendor
- February 17: Roy Hobbs, television news anchor
- February 17: Tony Pardi, leather worker
- March 5: John Buchanan Jr, former Baptist minister and U.S. Representative
- March 9: Kumar, a Malayan tiger
- March 18: Frank Fleming, sculptor
- See also, List of homicides in 2018.
- BrickTop's restaurant at 2800 U.S. Highway 280
- Grandview Cancer Center
- March 20: Kiwanis Centennial Park at Vulcan Park and the head of Vulcan Trail
- Thompson High School
- W. C. Davis School, for Lakeview Green
- Salvation Army Social Services Center on 11th Avenue South, for BJCC expansion
- Paul S. Worrell Building by UAB for a future parking deck
In 2018 China's National People's Congress eliminated presidential term limits.
The Philadelphia Eagles beat the New England Patriots in Super Bowl LII. The 2018 Winter Olympics were held in PyeongChang, South Korea.
The Pritzker Prize for architecture was awarded to Balkrishna Doshi.
Notable deaths in 2018 included those of actors David Ogden Stiers and Jerry Van Dyke, Ikea founder Ingvar Kamprad, activist John Perry Barlow, author Ursula K. Le Guin, cartoonist Mort Walker, distance runner Roger Bannister, evangelist Billy Graham, fashion designer Hubert de Givenchy, physicist Stephen Hawking, New Orleans Saints owner Tom Benson, sportscaster Keith Jackson, and musicians Hugh Masekela and Dolores O'Riordan.
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