Crowe graduated from Troy High School in 1955 and earned his undergraduate degree at Howard College and continued with medical studies at the University of Alabama Medical College. He completed his internship and surgical residency at Lloyd Noland Hospital and a residency in urology at UAB Hospital.
As a practicing urologist, Crowe helped establish Alabama's first freestanding physician-owned outpatient surgery center, where he pioneered outpatient treatment for kidney stones. He established the Alabama Renal Stone Institute at Brookwood Medical Center, which operated the state's first lithotriper.
At the request of the Alabama State Medical Association, Crowe led a group of physicians that founded the Mutual Assurance Society of Alabama in 1976. That agency, which became known as the Medical Assurance Company, combined with the Professionals Group, Inc. of Michigan in 2001, forming ProAssurance with Crowe as Chief Executive Officer. He was named Alabama CEO of the Year by the Birmingham News in 2005. Stan Starnes, the company's former legal counsel, succeeded Crowe after his retirement in 2007. He remained Chairman of the Board until his resignation in September 2008, shortly following the death of his daughter, Christina.
- DeButts, Jimmy (April 26, 2007) "ProAssurance taps Starnes as new CEO." Birmingham Business Journal
- DeButts, Jimmy (September 22, 2008) "UA to induct local leaders into Alabama Business Hall of Fame." Birmingham Business Journal
- DeButte, Jimmy (September 23, 2008) "ProAssurance Chairman Derrill Crowe resigns." Birmingham Business Journal
- Aubrey Derrill Crowe, MD at healthcarehof.org