Early settlers along Georgia Road included Obadiah and Edmund Wood at what became Woodlawn, Abner Killough at the "Big Spring" in present-day Avondale, Warren and Sam Truss at Trussville, Daniel Huffman at Huffman, Burrell Bass at Roebuck, and Richard B. Walker and William F. Nabers, whose lands included the area that would become the city of Birmingham. The road also traversed the grant given to William Ely on which Elyton was laid out in 1820. It was renamed "Cotton Avenue" within the town limits.
Georgia Road connected to Montevallo Road (also called Bear Meat Cabin Road or the Nashville to Montgomery Road) at Red Gap near what became Gate City. It crossed the Huntsville Road, Tuscaloosa Road and Arkadelphia Road at Elyton.
U.S. Highway 78 (Atlanta Highway) follows roughly the route of Georgia Road east of Birmingham.
The road reappears as it splits off from 1st Avenue South just before 57th Street South in Woodlawn, continuing eastward below I-20, through Gate City, below Oporto-Madrid Boulevard and on into Irondale where it is renamed 2nd Avenue North as it crosses 16th Street North.
- Messer Airport Highway
- 1st Avenue North intersects
- 1st Avenue South
- 6200 block: Old Ship A.M.E. Zion Church
- 6200 block: Eagles Nest Church of God in Christ
- 6300: former location of J. E. Smith restaurant (1910)
- 6517: Allright Tool Company
- 6601: Glorious Light Church
- 6910: vacant, former location of Gate City Elementary School (1955-2011)
- 7407: Holy Rosary Catholic Church (1889-)
- 7429: Miller Wire Works
- Interlaken Avenue intersects (north only)
- Red Gap
- Oporto-Madrid Boulevard crosses above