January 21 in the history of the Birmingham District:
- 2017: The 2017 Women's March was held to promote women's rights as human rights.
- 2014: Continental Bakery Downtown opened at One Federal Place.
- 2009: E. B. McClain and Samuel Pettagrue were found guilty of bribery, money laundering and mail fraud in Federal court.
- 2007: ChristWay Church's newest building was dedicated in Gardendale.
- 2007: Hugh Cort officially began his campaign for the Republican nomination for President of the United States.
- 1985: Birmingham's record low temperature of -6°F was set.
- 1973: A "buildingwarming" was held to open the Vulcan Life building on Valley Avenue.
- 1965: The Birmingham Area Committee for Development of Economic Opportunity was incorporated.
- 1952: The First Bank of Alabaster opened.
- 1940: John A. Carroll was invested into the Order of St Gregory by Pope Pius XII.
- 1922: The Birmingham Flying Club was recognized as the 135th Observation Squadron of the Alabama National Guard.
- 1832: The city of Centreville was incorporated.
- 1969: Professional baseball player Rusty Greer was born at Fort Rucker.
- 1966: Vestavia, UAB and professional baseball player Chris Hammond was born in Atlanta.
- 1952: Actor, communications consultant and former football player Thom Gossom Jr was born in Birmingham.
- 2021: Musician and minister Marc Phillips died from COVID-19.
- 2020: College football star De'Runnya Wilson died in an apparent homicide in Mason City.
- 2019: Former Mayor of Hoover Gary Ivey died at home in Clanton.
- 2010: Baseball player, manager and executive Bobby Bragan died in Fort Worth, Texas.
- 1991: Wrestling promoter Nick Gulas died in Nashville, Tennessee.
- 1964: Jefferson County Personnel Board president Howard Yeilding died in Birmingham.
- 1905: Alderman and Chancellor John Altman died.
- 2014: Bill Clark was named to succeed Garrick McGee as head coach of the UAB Blazers football team.