June 21 in the history of the Birmingham District:
- 2006: The ribbon-cutting ceremony for Rosedale Senior Apartment Homes was held.
- 2005: The week-long charrette for Mainstreet Trussville began.
- 2004: SouthTrust Bank's sale to Wachovia Bank was announced.
- 2001: President George W. Bush visited the Birmingham area.
- 1954: The Pickwick Players debuted at the Pickwick Club at Five Points South.
- 1947: Reverend Joseph Adams was appointed the first resident pastor of Holy Infant of Prague Catholic Church in Trussville.
- 1941: Businessman William D. Sulzby married Mildred Wood.
- 1876: Pastor Benjamin Franklin Riley married Emma Shaw.
- 1972: Birmingham communications director April Odom was born.
- 1964: Pastor Chris Hodges was born.
- 1953: Catcher Charlie Moore was born in Birmingham.
- 1950: Mayor of Oneonta Danny Hicks was born.
- 1941: Gospel and R&B singer and minister Mitty Collier was born in Birmingham.
- 2018: Judge William Acker died.
- 2014: Former WBRC-TV news anchor Joe Langston died.
- 2007: Birmingham Zoo elephant Mona was euthanized.
- 2005: Former U.S. Marine Corps Commandant Louis Wilson Jr died in Birmingham.
- 1924: Motorcycle racer Gene Walker died from injuries sustained in a crash in Pennsylvania.