Oxmoor Road is an approximately three and three-quarters mile long street running mostly roughly northeast-southwest through Homewood between Independence Drive (U.S. Highway 31) and West Oxmoor Road. It is part of a road dating back to at least the 1860s which was previously known as Oxmoor-Irondale Road and connected the Cahaba Iron Works in Irondale with Oxmoor Furnace in Oxmoor, hence the road's name.
In the 1860s, Oxmoor-Irondale Road was used to haul pig iron from both Irondale and Oxmoor south to Selma. The road was also important for early settlers of Shades Valley as it was easier to use it to access the two furnace's commisary stores for supplies than to cross Red Mountain to Elyton, or later Birmingham, for them. It was along this road that the settlements that would eventually become Homewood took shape. At some point in the first half of the 20th century, the road became known simply as Oxmoor Road.
Most of Oxmoor Road was resurfaced in 1949.
During the late 20th century, two bypasses were created along Oxmoor Road. First, during the 1970s, Oxmoor Boulevard was built north of Oxmoor Road to provide light industry that appeared on West Oxmoor Road a multi-lane route to I-65 and avoid a residential area. Oxmoor Road intersects both ends of Oxmoor Boulevard. Second, during the late 1980s, Palisades Boulevard and Palisades Drive routed traffic through the Palisades shopping center to Green Springs Highway. In this case, direct access into the residential section along Oxmoor was cut off as Oxmoor feeds directly into the two Palisades roads.
 Road description
Oxmoor Road is one of the primary east-west roads through Homewood, although the majority of it, except for some left turn lanes at select intersections, is two-lane road. Oxmoor is a five-lane road between Columbiana Road and east end of Oxmoor Boulevard (near Green Springs Highway and Interstate 65) and between the west end of Oxmoor Boulevard and West Oxmoor Road. At the intersection with the west end of Oxmoor Boulevard, Oxmoor Road makes a 90-degree turn to the south. It then forms a fork with West Oxmoor Road and becomes West Oxmoor for those traveling south. The eastern end of Oxmoor Road becomes Hollywood Boulevard.
Just south of the Palisades, Oxmoor Road is on the Birmingham-Homewood border. Between Oxmoor Boulevard and West Oxmoor Road, portions of Oxmoor Road are fully in Birmingham while others are again along the Birmingham-Homewood border.
 Notable locations
For an alphabetical list of locations, see the Oxmoor Road category.
- West Oxmoor Road intersection (continues south as West Oxmoor Road)
- Oxmoor Boulevard/Barber Court intersection
- Oxmoor Boulevard intersection
- Interstate 65 interchange
- Green Springs Highway intersection
- Columbiana Road intersection
- 500 block: Traffic diverted on to Palisades Boulevard/Palisades Drive
- 850: Edgewood Presbyterian Church
- Edgewood Business District
- Broadway Street intersection
- Edgewood Business District continued
- 1001: Trilogy Leather
- 1003: Edgewood Frame Shop (formerly Bill's Hobby Shop and TV Sales and Service)
- 1006: La Bamba Grill
- 1008: Saw's BBQ (formerly Broadway BBQ)
- 1010: New York Pizza
- 1014: Hart & Soul Coffee Company (formerly Cool Beans Coffee House and New York Pizza)
- 1016: Night Owl Paper Goods
- 1018: The Ruby Begonia
- 1019: Dawson Memorial Baptist Church Family Recreation Center (former location of Colonial Stores grocery)
- 1114: Dawson Memorial Baptist Church
- 1400: Trinity United Methodist Church
- 1629: Applause Dancewear
- 1632: Homewood Park/Homewood Department of Parks and Recreation
- Edgewood Business District continued
- Central Avenue intersection
- Crescent Avenue intersection (north only)
- 1740: formerly Resolutions LLC
- Linden Avenue intersection (north only)
- 18th Street South intersection
- 19th Street South/Firefighter Lane intersection
- Cook Street intersection (south only)
- Drake Street intersection (south only)
- Independence Drive intersection (continues east as Hollywood Boulevard)
- Summe, Sheryl Spradling. (2001). Homewood: The Life of a City. Homewood, AL: Friends of the Homewood Public Library.