Arkadelphia Road is the section of U. S. Highway 78 running from 8th Street West/Princeton Parkway at 2nd Court West northward to Finley Boulevard in Fountain Heights. It is named because it once connected Birmingham to the Cullman County community of Arkadelphia. A Blount County road connecting Jefferson County Highway 89 at Warrior-Jasper Road and Cullman County Highway 35 at Mulberry Fork is also named Arkadelphia Road.
Part of Arkadelphia Road in Birmingham once carried the No. 7 Wylam-Bush Hills streetcar line.
 Notable locations (south to north)
- For an alphabetical list of locations, see the Arkadelphia Road category.
- continued from Princeton Parkway/8th Street West
- intersection with Graymont Avenue
- former location of Clark's Service Station
- 864: Omega Psi Phi
- 801: McCoy United Methodist Church
- 900: Birmingham-Southern College
- I-20/59 interchange
- 11th Court West (Day's Inn Birmingham)
- 1137: 78 Shell
- 1148: Ark Chevron
- 1164: Amoco
- Duke Park (East Thomas Park)
- Thomas Overpass (Birmingham Southern Railroad)
- Village Creek
- 1223: Charlie's Cafe