Drennen was the son of Reverend Walter Blythe and Matilda Cornwell Drennen of Walker and Blount counties. He attended the common school in Arkadelphia and settled in Birmingham where he pursued his career in business. He served as a member of the firm of Drennen & Company and president of the Martin Cracker Company. He managed the Palos Coal & Coke Company and was a member of the board of directors for the Birmingham Mutual Fire Insurance Company.
Drennen was elected mayor in the 1899 Birmingham mayoral election and re-elected to twice to two-year terms. He was presiding as mayor at the completion of the Birmingham City Hall in 1901 and served as president of the League of Alabama Municipalities.
F. V. Evans
|Mayor of Birmingham|
1899 - 1905
- Dubose, Joel Campbell (1904) Notable men of Alabama: Personal and Genealogical Atlanta, Georgia: Southern Historical Association
- Owen, Thomas McAdory and Marie Bankhead Owen (1921) History of Alabama and Dictionary of Alabama Biography. 4 volumes. Chicago, Illinois: S. J. Clarke Publishing Co.
- Causey, Donna (June 14, 2009) "Drennen, Walter Melville (1851-aft. 1904)" Alabama Pioneers