- April 29: Walker Memorial United Methodist Church was organized in Frog Level.
- Bear Meat Cabin was founded as the first settlement in what's now Blount County.
- The Roebuck, Reed and Truss families began settling in the area of Center Point.
- December 2: William Mudd, attorney and judge
- December 20: Shandy Jones, politician
- December 24: Moses Fields
In 1816, Gioachino Rossini's The Barber of Seville debuted at Teatro Argentina. The African Methodist Episcopal Church was established by Rev. Richard Allen and other African-American Methodists. Lord Byron, Mary Wollstonecraft Godwin, Percy Bysshe Shelley, and John Polidori, gathered at the Villa Diodati in Switzerland, giving rise to Mary Shelley's Frankenstein and Polidori's The Vampyre. Argentina gained independence from Spain. James Monroe defeated Rufus King in the U.S. presidential election. Indiana was admitted as a state. E. Remington and Sons was founded. Robert Stirling patented his Stirling engine.
Notable births in 1816 included novelist Charlotte Brontë, shipbuilder William H. Webb, rugby ball inventor Richard Lindon, actress Charlotte Saunders Cushman, army general George Henry Thomas, and inventor and industrialist Werner von Siemens. Notable deaths included social science pioneer Adam Ferguson, Queen Maria I of Portugal, playwright Richard Brinsley Sheridan, and U.S. founding father Gouverneur Morris.
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