- June 5: The Jefferson County Orphans' Court met for the first time at the newly-built Jefferson County Courthouse in Carrollville.
- July 10: William Wyatt Bibb died, making his brother and President of the Senate, Thomas Bibb, Governor of Alabama.
- December 18: The General Assembly of Alabama established the University of the State of Alabama's Board of Trustees to oversee its construction and operation.
- Blountsville was established as the first county seat of Blount County.
- Cahawba County was renamed Bibb County.
- Infant Walter Drennen and his mother arrived at their homestead on the Mulberry River near Hamby's Mill.
- Trussville was established.
- David Buck opened a general store at Bucksville.
- The river port settlement of Baltimore on the Mulberry Fork in Blount County was advertised.
- December 20: Elyton was incorporated.
- William B. Arnold became the Shelby County Sheriff.
- Thomas Smith became the first Probate Judge for Shelby County.
In 1820, George IV of the United Kingdom ascended the throne. The Missouri Compromise became law. Maine was admitted as a state. The Venus de Milo was discovered.
Notable births included Union general William Tecumseh Sherman, suffragist Susan B. Anthony, nurse Florence Nightingale, and philosopher Friedrich Engels. Notable deaths included King George III of the United Kingdom, naval hero Stephen Decatur, botanist Sir Joseph Banks, and pioneer Daniel Boone.
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