- November 22: Benjamin Fitzpatrick became Governor of Alabama.
- Howard College (later renamed Samford University) was founded in Marion.
- Jones-Bailey Cemetery was established.
- August 25: Peter Anderson reclaimed the office of Jefferson County Sheriff from Moses Kelley.
- December 22: William Mudd married Florence Jane Earle.
- Walter Drennen married Matilda Drennen.
- Joseph Riley Smith completed his medical studies at the Transylvania Medical College in Lexington, Kentucky.
- May 26: Charles Whelan, physician
- August 15: Julia Tutwiler, educator and social reformer
- Charles Hooper, merchant
In 1841, the Second Seminole War and the First Opium War continued. The United Kingdom of Great Britain and Ireland occupied Hong Kong. William Henry Harrison became President, died one month later, and was succeeded by Vice President John Tyler. A fire at the Tower of London destroyed its Grand Armoury. The city of Dallas, Texas was founded.
Notable births in 1841 included explorer Henry Morton Stanley, painter Pierre-Auguste Renoir, Supreme Court Justice Oliver Wendell Holmes Jr, assassin Charles J. Guiteau, statesman Georges Clemenceau, and King Edward VII of the United Kingdom. Notable deaths included guitarist Ferdinando Carulli, President William Henry Harrison, philosopher Franz Xaver von Baader, artist David Wilkie, murder victim Mary Rogers, and politician John Chandler.
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