Speake graduated from Oconee County High School in Watkinsville, Georgia. She completed a bachelor's degree in biology at UAB in 2021. She has previously worked as a teaching assistant, housekeeper, cook, server, tutor, courier, and office specialist.
Speake has canvassed for Planned Parenthood Southeast, and is a member of the Cell A65 executive committee. She previously volunteered on campaigns for Doug Jones, Danner Kline, Ryan Jones, Jenn Gray, Quang Do, and Elizabeth Warren.
On June 29, 2021 she qualified to run for the Birmingham City Council District 3, in the 2021 Birmingham municipal election. As a candidate she pledged to prioritize environmental justice, rent control, sustainable housing, infrastructure, accessibility, public amenities, public health and small business support. She came in second place, with 28.71% of the vote, out of four candidates, losing to 20-year incumbent Valerie Abbott.
In August 2022 Speake was elected as an at-large member of the Alabama State Democratic Executive Committee, where she now serves on the LGBTQ+ Caucus. She also serves as a member of the LGBTQ+ and Disability Caucuses of the Jefferson County Democratic Executive Committee.
On September 6, 2022 she filed to run as secretary of the Glen Iris Neighborhood Association during the October 18, 2022 Birmingham neighborhood elections. Speake won 69.5% of the vote. Her term started January 31, 2023. She was elected Secretary of the Southside community on February 18, 2023.
- "Who’s Running For Birmingham City Council?" (August 16, 2021) WBHM.org/Birmingham Watch
- "Birmingham City election results" "CBS42"
- Alice Speake campaign website