2022 is the 151st year after the founding of the City of Birmingham.
- January 6: InCare Technologies was acquired by Thrive of Foxborough, Massachusetts.
- January: The Books-A-Million at Brook Highland Plaza closed.
- Spring: Macy's at Brookwood Village closed.
- May: Birmingham Xpress rapid transit system began operation.
- May 25–29: 2022 SWAC Baseball Tournament was held at Regions Field
- July 7–17: The 2022 World Games were held in Birmingham.
- Magic City Classic
- November 26: 2022 Iron Bowl
- January 13: Robert Evans succeeded Sean Calhoun as head football coach at Vestavia Hills High School.
- January 7: Janae Pierre left WBHM-FM to host a podcast for New York Public Radio.
- January 2: Maxine McNair, retired teacher
- January 2: Fred Dyess, antiques dealer
- January 7: Victor Hanson II, Birmingham News publisher
- January 11: Tanya Canada, Mayor of Dodge City
- January 15: Rickey Powell, vocalist and actor
- A. G. Gaston Motel restaurant renovations
- Alabama Aerospace & Aviation High School
- Replacement for Ramsay-McCormack building
- Powell Avenue Steam Plant
- Birmingham Realty Co. Warehouse
- 20 Midtown phase 3
- 2323 2nd Avenue South
- Carver Theatre (renovations)
- Citywalk BHAM
- Grandview Physicians Plaza II
- Hampton Inn & Suites by Hilton - Fultondale
- Legacy Arena renovation and expansion
- The Marshall
- Mountain Brook Junior High School expansion
- Parkside on Dolly Ridge
- Way Station for AIDS Alabama in Smithfield
- Woodlawn High School football stadium & fieldhouse
A volcanic eruption at Hunga Tonga on January 15 caused tsunami flooding across the Pacific.
Notable people who died in 2022 included actor Sidney Poitier; anthropologist Richard Leakey; film director Peter Bogdanovich; and football coach Dan Reeves.
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