Huff earned a bachelor's degree in broadcast journalism at West Virginia University in 1975. She worked at WSAZ-TV in Huntingdon, West Virginia and Tampa, Florida before coming to Birmingham in 1977 to succeed Wendell Harris as evening news co-anchor on WAPI-TV (NBC 13). She was the first woman to anchor an evening newscast in the Birmingham market.
The station was renamed WVTM in 1980. Huff and fellow anchor Tracy Haynes left Channel 13 for the newly-created WBMA in 1996. She co-anchored the "Good Morning Alabama" program there until taking the lead on her own afternoon magazine program, Focus @ 4:00, in 2011. She later resumed working as a news anchor for the station's 4:00 PM and 5:00 PM newscasts.
In 2022 Huff was diagnosed with aggressive breast cancer.
She and her husband, Bill, have two daughters and two grandchildren.
- Hollis, Tim (2006) Birmingham Broadcasting. Images of America series. Charleston, SC: Arcadia Publishing. ISBN 0738542717
- Carlton, Bob (July 26, 2011) "Maggie Poteau rejoins Birmingham's ABC 33/40; Pam Huff leaves mornings to begin afternoon show." The Birmingham News
- Koplowitz, Howard (July 20, 2022) "ABC 33/40 anchor Pam Huff reveals breast cancer diagnosis: God ‘has me every single step of the way’." The Birmingham News