Rugby Avenue is a mostly residential street that loops through South East Lake from Oporto-Madrid Boulevard (formerly 77th Street South) to 83rd Street South. It formerly carried the South Highlands Car Line streetcar (Birmingham Electric Company Route 36), which served Howard College. The street serves as part of the boundary of the Howard College Estates Historic District.
- 7752: Oxford Apartments
- 8038: The Rugby Building former location of Asian Food Mart (1983), U-Haul, T'Lee's on Rugby salon, Project Success, Debt Relief Counseling Services, Dream World Overcoming Holiness Church child care center, Kingdom Care Academy
- 8041: Ruffner Relics, former location of Sadler's Food Store (1964), Handy Pack Convenience Store (1970), Deliverance of Truth Ministry
- 8236: Rugby Avenue Market / Rugby Avenue Delicatessen, Sea Land Fish & Chips