Hutson attended the University of Alabama from 1932 to 1935, and was a team-mate of Bear Bryant. Hutson earned All-Southern and All-American honors, starred in the Rose Bowl and made a place for himself on the "All-Time Alabama Team".
Hutson played professional football eleven years for the Green Bay Packers. During those seasons (1935 to 1945), he led the NFL in scoring 5 years with 138 points in one year and a career total of 823. Green Bay won 87 games during Hutson's tenure. The Packers have honored Hutson by retiring his #14 jersey, a first for Green Bay, and named their indoor practice facility the "Don Hutson Center." Hutson was a charter member of both the college and professional Football Halls of Fame, as well as the Alabama Sports Hall of Fame.