Mayomi grew up in Birmingham and graduated from Hayes High School. She completed a bachelor's degree from Alabama State University in 1987 and a master's degree in education at UAB in 1999. After a fifteen year career at Jefferson State her position was eliminated. In 2006 she declared personal bankruptcy to avoid losing her home.
Mayomi qualified in the 2009 special election to fill the vacancy left by Larry Langford. If elected, she hoped to improve educational opportunities, access to health care, and support for the unemployed and homeless in the city. Mayomi finished 12th of the 14 candidates with 28 of the 34,931 votes cast.
- Faulk, Kent (December 1, 2009) "Birmingham mayor's race: Edith Mayomi wants to help homeless, jobless." Birmingham News