Rose grew up in Seattle and earned a bachelor's degree in architecture at the University of Oregon. After marrying Pat Byington she moved to Birmingham and took a job with Highland Partners architects, then remained with Carraway & Associates after the partnership split.
She grew up in a family of talented crafters and became interested in creating leaded, fused, etched and blown glass art. She pursued that interest in college and later through courses at the Pilchuck Glass School in Washington. She developed a particular interest in re-using vintage glass objects and cast-offs collected from antique stores, flea markets, and beaches in ornamental constructions. She has created commissioned work for architectural clients and others, including St Andrew's Episcopal Church. She exhibited a series of leaded-glass boxes and folding books in a group show of glass art at Agnes gallery in April 1997. Since then her work has been shown at galleries in Decatur and Florence and at Bare Hands in Birmingham.
Rose-Byington became president of Bare Hands' board of directors in 2007 and later served as executive director. In 2013 she was elected to the Board of Directors for the Girl Scouts of North-Central Alabama. She and her husband have one daughter, Whitney.