Latham briefly lived in Riyadh, Saudi Arabia with her family before they settled in Birmingham in 1984. She graduated from Hewitt-Trussville High School in 1988 and went on to earn degrees in social work at UAB and the University of Alabama.
Latham's poetry has been anthologized in several publications, and was collected in a 2007 compilation entitled What Came Before, which earned a Bronze Idependent Publishers Award and was named Book of the Year by the Alabama State Poetry Society. Her debut novel, published in 2010, is a "mid-grade" historical fiction telling the story of a young girl growing up in 1930s Gee's Bend.
- Latham, Irene (2007) What Came Before. Mobile: Negative Capability Press ISBN 9780942544619
- Latham, Irene (2010) Leaving Gee's Bend. New York, New York: G. B. Putnam & Sons ISBN 9780399251795
- Swagler, Susan (May 2010) "Stitching together a story." Birmingham magazine. Vol. 50, No. 5, p. 28
- Irene Latham website