Hampton transferred from Wilkerson Elementary School to Holy Family Elementary School for grades 2 through 8. He graduated from Parker High School in 1992, where he sang in the choir and played played defensive end and left tackle for the Thundering Herd football team and forward on the basketball team. He also participated in the Southeastern Consortium for Minorities in Engineering and INROADS programs for high-achieving students. Through his mother's efforts he connected with Wendell Hunt of BE&K who mentored him through college.
Hampton earned a full scholarship to Stillman College to begin an engineering program that concluded with two years at the University of Alabama, where he completed his bachelor of science in electrical and electronics engineering in 1998.
While in college, Hampton worked as a tactical manager for system integrity for Alagasco. After graduation he was assigned to the utility's engineering department where he came to the notice of Ken Smith, who became another strong mentor for him and later became president of the company.
Hampton was promoted to vice president for field operations for Spire Inc., based in Kansas City, Missouri, in 2015. He returned to Birmingham to succeed Smith as president of Spire Alabama in December 2018.
Hampton and his wife, Jenise, have two sons, Joseph II and Jonathan.