A graduate of the UAB School of Medicine, Lemak was a founding partner, along with James Andrews, of Alabama Sports Medicine and Orthopaedic Center, one of the nation's leading orthopaedic clinics. In 2007, Lemak and Andrews split amicably, dissolving the ASMOC. Lemak and his son David founded the Lemak Sports Medicine practice at Brookwood Hospital that November.
Lemak has played an integral role in sports medicine and arthroscopy research as one of the founders and board members of the American Sports Medicine Institute, a research and education center. He is also a founder of the National Center for Sports Safety. He serves as Medical Director for Major League Soccer, NFL Europe, Professional Golf Association, the United Football League and the Ladies Professional Golf Association. He is also Team Physician for many colleges and universities including Auburn University, Samford University, Birmingham-Southern College, Alabama State University, Miles College and the University of Montevallo.
Lemak was inducted into the Alabama Sports Hall of Fame in 1997. He was president of the CFL's expansion team, the Birmingham Barracudas. He was a proponent of the MAPS proposal, and worked to bring soccer matches to Legion Field during the 1996 Olympics. He has also been a long-time proponent of the proposed dome.
- Velasco, Anna (February 14, 2008) "Dr. Larry Lemak moves practice to Brookwood." The Birmingham News
- Solomon, Jon (October 8, 2009) "Dr. Lemak serves as new UFL medical director." The Birmingham News
- Howard, Ingrid (January 22, 2019) "Room and a View: The Lemaks Decision to Downsize Opens up Their Former Home to be the 2019 Decorators’ ShowHouse." Over the Mountain Journal.
- Larry Lemak at the National Center for Sports Safety