September 15 in the history of the Birmingham District:
- 2010: Trinity Medical Center received approval from the State Certificate of Need Review Board to relocate to the vacant HealthSouth digital hospital on U.S. Highway 280.
- 2007: We Love West End Day was held at Rickwood Field.
- 2004: The Shelby County Arts Council was incorporated.
- 2003: Bogart's Motorsports opened in Irondale.
- 1978: James H. Woodward became the second dean of the UAB Department of Engineering.
- 1975: Birmingham officially kicked off its Bicentennial celebrations.
- 1970: Five members of the Alabama Black Liberation Front sat in ambush of Jefferson County Sheriff's Deputies sent to evict Beatrice Turner from her home in Tarrant City. The only shots fired were from law enforcement. All five were arrested.
- 1963: 16th Street Baptist Church was bombed.
- 1958: Cousin Cliff's "The Popeye Show" debuted on WABT-TV.
- 1934: Governor Fob James was born in Lanett.
- 1911: Surgeon General Luther Terry was born in Covington County.
- 1891: Nouna Illges was born in Muscogee County, Georgia.
- 1852: Shiloh Baptist Church founder Thomas Walker was born in Coosa County.
- 1973: Political activist and fraudster Christopher Key was born.
- 2013: Chelsea founder John Ritchie died in an auto collision on U.S. Highway 280.
- 2010: Former Birmingham-Southern College provost Irvin Penfield died.
- 2008: Dry cleaner Brooksie Lovvorn died.
- 2008: Alabama State University football coach George James died.
- 2008: Musician Dennis "The Rock" Dumas died.
- 1994: Saxophonist Haywood Henry died in the Bronx, New York.
- 1963: Addie Mae Collins, Denise McNair, Carole Robertson, and Cynthia Wesley were killed in the 16th Street Baptist Church was bombing..
- 1963: 16-year-old Johnnie Robinson was killed by police after throwing rocks at cars.
- 1963: Virgil Ware was shot and killed while riding on the handlebars of his brother's bicycle in Docena.
- 1940: U.S. Speaker of the House William Bankhead died in Washington D.C.
- 1936: Historian and newspaper editor George Cruikshank died.
- 2007: BSC Panthers lost 10-7 to Rhodes College at Regions Park.
- 2007: UAB Blazers won 22-0 over Alcorn State at Legion Field.
- 1979: The Alabama Vulcans lost 28-21 at the Florida Firebirds.
- 1973: The 1973 Auburn Tigers football team defeated Oregon State Beavers18-9 and the 1973 Alabama Crimson Tide football team beat California Golden Bears 66-0 in the last Alabama/Auburn double-header at Legion Field.