September 22 in the history of the Birmingham District:
- 2015: Ace Graham opened the Alchemy boutique on 20th Street North.
- 2009: Interfaith Hospitality House dedicated its new center on 1st Avenue South.
- 2006: The 8th Annual Sidewalk Moving Picture Festival began in the Theatre District downtown.
- 2006: Female professional skywriter, Suzanne Asbury-Oliver, spelled "Airshow" over downtown Birmingham to advertise the Wings and Wheels Air Show at the Shelby County Airport.
- 2005: In the aftermath of Hurricane Katrina along the Gulf Coast, a New York congressman called President Bush "our Bull Connor".
- 1990: Highland Booksmith opened at Highland Towers.
- 1973: Leo and Susie Headrick purchased Green Top Bar-B-Q.
- 1969: Demolition of the Birmingham Terminal Station began.
- 1962: Two African Americans who attended the Alabama-Georgia game at Legion Field were assaulted by a crowd of as many as 100 white persons outside the game when they made their exit during the 4th quarter.
- 1912: The first Sunday edition of the Birmingham News was published.
- 1886: St John African Methodist Episcopal Church was incorporated.
- 1887: Engineer Herbert Salmon was born in Indiana.
- 1855: Presbyterian minister and educator James Hall was born in Monroe County, Tennessee.
- 2015: Football player and coach Richard Williamson died in Charlotte, North Carolina.
- 2009: Radio announcer Steve Norris died.
- 2001: Six people were killed in an apartment fire deliberately set in Fairfield.
- 1996: Businessman Ferd Weil died in Birmingham.