The Medical Arts Building was converted into Pickwick Hotel and Conference Center along with an adjacent conference center and retail development called Pickwick Plaza in 1988. Both developments were named for the former Pickwick Club, which had opened nearby the same year as the Medical Arts Building, and headed by cardiac surgeon Donald Kahn.
In November 2006 Atlanta developers Long & Cox Properties Inc. announced plans to purchase the hotel and embark on a estimated $7 million overhaul which would transform the property into a high-end boutique hotel and martini bar. They selected Denver, Colorado-based Richfield Hospitality Services to operate the hotel. Local designer Peggy Dye & Associates was announced as an equity partner and coordinated the interior design of the the hotel.
The Pickwick Hotel was closed in January 2007. It quietly reopened in early July 2008 as The Hotel Highland. The property was sold to SJP Investment Partners LLC of Atlanta, Georgia for $3.6 million in October 2016 and was converted into a Hotel Indigo. Marshall Hotels & Resorts of Salisbury, Maryland began operating the rebranded hotel in 2018.
- Nicholson, Gilbert (August 23, 2002) " 'Pickwick Club' provided name for hotel, retail plaza." Birmingham Business Journal
- Tomberlin, Michael (November 2, 2006) "Atlanta developers buy Pickwick Hotel." The Birmingham News
- Cooper, Lauren B. (March 9, 2007) "High end in Five Pts." Birmingham Business Journal
- Kent, Dawn. (July 24, 2007) "Former Pickwick gets new name, updated look." The Birmingham News
- Godwin, Brent (October 13, 2016) "Historic Five Points South hotel purchased for $3.6M." Birmingham Business Journal
- West, Ty (February 27, 2017) "Prominent Birmingham hotel to become a Hotel Indigo." Birmingham Business Journal