- January 7: William Pullen was granted an 80-acre tract near what later became Avondale.
- December 23: The Alabama Legislature commissioned Abraham Stouts to construct a public road from Morgan County to the Black Warrior River.
- Ashville was incorporated.
- Bear Meat Cabin Road was recognized as a Federal Post Road.
- Dent was first settled.
- The Wilsonville Post Office was established.
- The University of Alabama Board of Trustees was expanded from 12 to 18 members.
- Hosea Holcombe became pastor of Canaan Baptist Church in Jonesboro.
- Rock Creek Baptist Church was founded.
- February 4: Matthew Duffee and his family arrived at Charleston, South Carolina after emigrating from Ireland.
- October 5: John McWhorter succeeded Levi Reid as Jefferson County Sheriff.
- December 12: John Williams Walker resigned as Alabama's first senator due to failing health.
- Ezekiel Henry succeeded William B. Arnold as Shelby County Sheriff.
In 1822, Charles Babbage proposed a Difference engine. Brazil declared its independence from Portugal. Egyptian hieroglyphs were deciphered by Thomas Young and Jean-François Champollion, using the Rosetta Stone. The American Colonization Society established Liberia in Africa as a place for freed slaves.
Notable births in 1822 included physicist Rudolf Clausius, archeologist Heinrich Schliemann, naval officer and explorer Edward Fitzgerald Beale, eugenicist and meteorologist Francis Galton, landscape architect Frederick Law Olmsted, President Ulysses S. Grant, geneticist Gregor Mendel, President Rutherford B. Hayes, and microbiologist Louis Pasteur. Notable deaths included Ali Pasha of Tepelena, banker Thomas Coutts, author E. T. A. Hoffmann, poet Percy Bysshe Shelley, foreign secretary Lord Castlereagh (suicide), and astronomer William Herschel.
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