- December 10: Joshua L. Martin became the 12th Governor of Alabama.
- Lawler Cemetery was established near Robbins Crossroads.
- The Jones Valley Times began publication.
- July 16: Benjamin Franklin Riley, president of Howard College
- October 5: Robert Mustin, entrepreneur
- November 3: Bob McKinley, postmaster and Mayor of East Lake
In 1845, Congress established the first Tuesday after the first Monday in November as the uniform date for federal elections. Edgar Allan Poe's The Raven was first published. James K. Polk became president. Florida and Texas became states. Henry David Thoreau embarked on a two-year experiment in simple living at Walden Pond. Scientific American began publication. The Irish Potato Famine began. Frederick Douglass published his autobiography.
Notable births in 1845 included mathematician Georg Cantor, physicist Wilhelm Röntgen, naval hero Horatio Nelson Young, and writer Joel Chandler Harris. Notable deaths included pioneer Johnny Appleseed; President Andrew Jackson; United Kingdom Prime Minister Charles Grey, 2nd Earl Grey; and humanitarian Elizabeth Fry.
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