September 22 in the history of the Birmingham District:
- 2009: Interfaith Hospitality House dedicated its new center on 1st Avenue South.
- 2007: Samford defeated Southeast Missouri 26-21 at Seibert Stadium.
- 2006: The 8th Annual Sidewalk Moving Picture Festival began in the Theatre District downtown.
- 2006: The nation's only female professional skywriter, Suzanne Asbury-Oliver, spelled "Airshow" over downtown Birmingham to advertise the Wings and Wheels Air Show at the Shelby County Airport.
- 2005: In the aftermath of Hurricane Katrina along the Gulf Coast, a New York congressman called President Bush "our Bull Connor".
- 2001: Six people were killed in an apartment fire deliberately set in Fairfield.
- 1990: Highland Booksmith opened at Highland Towers.
- 1969: Willie Mays hit his 600th career home run.
- 1969: Demolition of the Birmingham Terminal Station began.
- 1968: The Boston Patriots lose to the New York Jets 47–31 at Legion Field.
- 1912: The first Sunday edition of the Birmingham News was published.