September 25 in the history of the Birmingham District:
- 2009: The Birmingham Zoo began dismantling the Monkey Island exhibit.
- 2009: The 11th annual Sidewalk Moving Picture Festival began.
- 2006: Russ and Dee Fine were fired during their radio show on WYDE-FM.
- 2004: Babec became the first gorilla to undergo the successful implant of a pacemaker.
- 2002: The Cahaba River National Wildlife Refuge was established.
- 1974: Sears opened their Century Plaza location.
- 1963: A pair of bombs were detonated on Center Street South.
- 1984: Birmingham Barons pitcher Justin Cassell was born in Northridge, California.
- 1961: State Representative Allen Treadaway was born.
- 1929: Founding North Shelby Fire Department Chief Winston Boutwell was born.
- 1928: Attorney, political consultant and author Vic Gold was born in East St Louis, Illinois.
- 1926: Center Point councilor Wink Chapman was born.
- 1910: Legendary Auburn Tigers football coach Shug Jordan was born.
- 1909 Physician Ben Carraway was born in Birmingham.
- 1904: Attorney and City Councilman Arthur Shores was born in Wenonah.
- 1866: Engineer and developer Henry Milner was born in Greenville, Butler County.
- 1861: Jefferson County Sheriff E. L. Higdon was born in Archville, Tennessee.
- 2012: Philanthropist Eleanor Kidd died.
- 2008: Actor Kent Lipham died in Los Angeles, California.
- 1971: Former Supreme Court Justice Hugo Black died.
- 1969: Sportswriter Benny Marshall committed suicide.
- 2005: Miles College defeated Stillman College in the Steel City Classic 13-10.
- 2004: UAB 35, Memphis 28 at Legion Field in the 7th Battle for the Bones.
- 1999: The Pelham Prowlers won 7-4 against the Jacksonville Hammerheads.
- 1965: Willie Mays hit his 50th home run of the season, becoming the oldest player to reach that total.