September 21 in the history of the Birmingham District:
- 2013: The Alabama Symphony Orchestra performed the world premiere of "A More Convenient Season" at the Alys Stephens Center.
- 2011: The Fairfield Civic Center was shut down during a political dispute.
- 2006: Construction began on the 2600 Highland Avenue condominium project.
- 2004: Skybucket Records released a compilation album entitled Low Dose Exposure.
- 1996: Robbie Fearn married Pamela Rowe.
- 1989: Samford University student Rex Copeland was murdered by his debate coach William Slagle.
- 1984: Writer Fred Bonnie married Wendy Watts.
- 1959: Shelby Memorial Hospital in Alabaster was dedicated.
- 1957: Attorney Orzell Billingsley married Geselda Hill.
- 1955: The remodeled La Paree restaurant opened at 2013 5th Avenue North.
- 1948: Alberta City was annexed into the city of Tuscaloosa.
- 1967: Software entrepreneur Jeff Trotman was born.
- 1957: Author Mark Childress was born in Monroeville, Monroe County.
- 1945: ADEM official Steve Spencer was born in Ohatchee,
- 1944: Fannie Flagg was born in Birmingham.
- 1940: Jefferson County Commissioner and former state representative Jim Carns was born in Blount County.
- 1919: Preservationist Marvin Harper was born in Northport.
- 1894: Homewood City Council member Frank Hambaugh.