September 15 in the history of the Birmingham District:
- 2010: Trinity Medical Center received approval from the State Certificate of Need Review Board to relocate to the vacant HealthSouth digital hospital on U. S. Highway 280.
- 2007: We Love West End Day was held at Rickwood Field.
- 2007: BSC Panthers lost 10-7 to Rhodes College at Regions Park.
- 2007: UAB Blazers won 22-0 over Alcorn State at Legion Field.
- 2004: The Shelby County Arts Council was incorporated.
- 2003: Bogart's Motorsports opened in Irondale.
- 1979: The Alabama Vulcans lost 28-21 at the Florida Firebirds.
- 1978: James Woodward became the second dean of the UAB Department of Engineering.
- 1975: Birmingham officially kicked off its Bicentennial celebrations.
- 1963: 16th Street Baptist Church was bombed.
- 1958: Cousin Cliff's "The Popeye Show" debuted on WABT-TV.
- 1940: U. S. Speaker of the House William Bankhead died in Washington D.C..
 Births and deaths
- 2010: Former Birmingham-Southern College provost Irvin Penfield died.
- 2008: Dry cleaner Brooksie Lovvorn died.
- 2008: Alabama State University football coach George James died.
- 2008: Musician Dennis "The Rock" Dumas died.
- 1994: Saxophonist Haywood Henry died in the Bronx, New York.
- 1963: Addie Mae Collins, Denise McNair, Carole Robertson, and Cynthia Wesley were killed in the 16th Street Baptist Church was bombing..
- 1963: 16-year-old Johnnie Robinson was killed by police after throwing rocks at cars.
- 1963: Virgil Ware was shot and killed while riding on the handlebars of his brother's bicycle in Docena.
- 1936: Historian and newspaper editor George Cruikshank died.
- 1934: Governor Fob James was born in Lanett.
- 1852: Shiloh Baptist Church founder Thomas Walker was born in Coosa County.