1823 was 48 years before the founding of the City of Birmingham and four years after Alabama became a state.
- The family of Richard Walker moved to Jefferson County from Missouri.
- December 26: Walker County was established.
- Matthew Duffee settled in Tuscaloosa.
- July 2: John Cullmann, city founder
- Isaac McGuire
- Alexander McLaughlin
- April 23: John Williams Walker, Alabama's first elected senator
- Orpah Moore, consort of Lemuel Moore
- Joe Waldrop built Waldrop's Mill on Valley Creek at the present site of the Toadvine community.
In 1823, the Basilica of Saint Paul Outside the Walls in Rome was almost completely destroyed by fire. James Monroe first introduced the Monroe Doctrine in the State of the Union Address.
Notable births in 1823 included biologist Alfred Russel Wallace, writer Ned Buntline, political boss William M. Tweed, aviation pioneer Félix du Temple de la Croix, and Orientalist Max Müller. Notable deaths included physician Edward Jenner, writer Ann Radcliffe, Pope Pius VII, and economist David Ricardo.
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