May 16 in the history of the Birmingham District:
- 2014: Maki Fresh opened its second Birmingham location at Wells Fargo Tower.
- 2009: The 30th Annual Do Dah Day was held on Highland Avenue.
- 2007: Daniel DeLong launched The Western Tribune in Bessemer.
- 2003: The 15th Annual City Stages kicked off in and around Linn Park.
- 1971: The eastern annex of the former Ullman High School was rededicated as the UAB Bell Building.
- 1954: Shades Crest Baptist Church was organized.
- 1916: The 1916 Reunion of the United Confederate Veterans began.
- 1904: Andrew Beard applied for a patent for an improved automatic railroad car-coupling.
- 1899: Andrew Beard's patent (no. 624,901) for an automatic railroad car-coupling was granted.
- 1871: Wallace S. McElwain sold his furnace and business to the Jefferson Iron Company.
- 1986: Actor Drew Roy was born in Clanton.
- 1963: Artist Jon Coffelt was born in Dunlap, Tennessee.
- 1916: Jazz trumpeter Dud Bascomb was born in Birmingham.
- 1903: Librarian William Hoole was born in Darlington, South Carolina.
- 1874: Attorney Rheuna Coffman was born.
- 1807: Blount County state senator Enoch Alldredge was born in Tennessee.
- 2023: Long-time Birmingham Chamber of Commerce president Don Newton died.
- 1947: Department store owner Robert Aland died.
- 1913: Madam Louise Wooster died.
- 2009: The fourth annual Birmingham Zoo Run was held.
- 1981: Athlete Carl Lewis, competing for the University of Houston, ran the 100-meter sprint in 10.00 seconds at the SWC championships.