November 21 in the history of the Birmingham District:
- 2015: Republican presidential candidate Donald Trump held a rally at the BJCC.
- 2008: Patti Wheeler signed off from WDXB-FM.
- 2007: George Bowman was appointed by Governor Bob Riley to fill the unexpired term of Jefferson County Commission member Larry Langford.
- 1975: The Smithsonian Institution sponsored performances of "The Music and Dance of the Age of Jefferson" at the BJCC Theater
- 1966: The Brother Bryan statue was relocated to Prayer Point at Vulcan Park.
- 1960: The first Jack's Hamburgers drive-in opened in Homewood and its "15-cent Jingle" debuted on local children's tv programs.
- 1939: Frances Moore began a 75+ year career at Bromberg's.
- 1938: Birmingham Commissioner of Public Safety Bull Connor and First Lady Eleanor Roosevelt stood off against each other during an integrated session of the 1938 Southern Conference for Human Welfare meeting at Municipal Auditorium.
- 1899: Birmingham's 1st Church of Christ Scientist was chartered.
- 1898: St Vincent's Hospital opened.
- 1948: Sculptor Elizabeth MacQueen was born in Birmingham.
- 1943: NYPD Detective Butch Ridley was born in Birmingham.
- 1933: Astronaut Hank Hartsfield was born in Birmingham.
- 1931: Mathematician and NASA official Clyde Foster was born in Birmingham.
- 1927: Contractor D. Riley Stuart was born in Greenville, Butler County.
- 1906: Boxer Petey Sarron was born in Birmingham.
- 2010: Actor Willis Burks died in Las Vegas, Nevada.
- 1987: Former governor Jim Folsom Sr died in Cullman.
- 1972: Jefferson County School Board member Owen Gresham died.