July 21 in the history of the Birmingham District:
- 2012: Jeremy Downey won the fourth Iron City Chef competition.
- 2008: WQOH AM 1480, owned by EWTN, began airing Catholic programming.
- 2008: Seafood D'Lite opened at 218 20th Street North.
- 2007: P&D Swords opened in Hoover.
- 2006: Java Jimz Cafe opened in Bessemer.
- 2006: Aqualung appeared at Art on the Rocks.
- 1977: The John Coe and Florence Jordan residences were listed on the Alabama Register of Landmarks and Heritage.
- 1956: The 1st Avenue North Alabama Farmers Market closed to relocate to Finley Avenue.
- 1944: The USS Birmingham participated in the Battle of Guam.
- 1943: William Mooney became president of the Southeastern Bible School.
- 1918: Lieutenant Frank Dixon's plane was shot down over Soissons, France.
- 1881: Attorney Emmet O'Neal married Elizabeth Kirkman.
- 2010: Kenya, a Greater kudu, was born at the Birmingham Zoo.
- 1924: Educator Angelena Rice was born in Hooper City.
- 1924: Restaurateur Frank Carnaggio was born.
- 1923: Construction leader Bill L. Harbert was born in Mississippi.
- 1883: Alabama Superintendent of Education Robert Tidwell was born in Blount County.
- 2006: Former University of Alabama marketing professor Harry Lipson Jr died in Tampa, Florida.
- 2005: Educator Theodore Lawson died.
- 1969: A. D. King drowned in his pool in Atlanta, Georgia.
- 1921: Birmingham Superintendent of Schools John Herbert Phillips died.
- 2007: Paul Edwards and Kelly Collins won the GT race at the Porsche 250.
- 2007: Alabama Steeldogs won 71-61 at the South Georgia Wildcats.
- 2001: Birmingham Steeldogs 67 - Memphis Xplorers 39 at Memphis, Tennessee.
- 1979: Alabama Vulcans 13 - Shreveport Steamers 7 at Shreveport, Louisiana.
- 1951: Catcher Sam Hairston made his major-league debut with the Chicago White Sox.