April 21 in the history of the Birmingham District:
- 2009: Outcasts United by Warren St John was published.
- 2008: The first shipment of Birmingham Schools' XO laptops was delivered to Glen Iris Elementary School.
- 2007: Ambassador's dinner with Bill Cabaniss and Petr Kolar as part of the Birmingham Festival of Arts' Spotlight on the Czech Republic
- 2006: Miss Alabama USA Haleigh Stidham finished in the top 10 at the Miss USA pageant.
- 2006 : Chris McNair was convicted on 11 counts of bribery and conspiracy as part of Jefferson County's sewer construction scandal.
- 1999: South Hampton Elementary School opened.
- 1988: Fire destroyed the interior of All Saints Episcopal Church in Edgewood.
- 1982: WTTO launched as Birmingham's first independent television station.
- 1976: Timothy Leary was released from Folsom Prison by California Governor Jerry Brown.
- 1969: The Center for Developmental and Learning Disorders was formally dedicated.
- 1949: The North Birmingham location of Hill's Food Stores held its grand opening.
- 1922: Duke Brothers Furniture Co. held the grand opening of their new store in the Duke Brothers building on 3rd Avenue North.
- 1883: The Phoenix Club was organized.
- 1999: Southern white rhinoceros Max was born.
- 1983: NFL and ASU football player Tarvaris Jackson was born in Montgomery.
- 1969: Music promoter and DJ Scott Register was born.
- 1968: Artist Cary Allbritton was born.
- 1947: Children's author Barbara Park was born in Mount Holly Township, New Jersey.
- 1938: Restaurateur Jimmy Koikos was born in Bessemer.
- 1931: Florist Martha Wilson was born.
- 1920: Poet Andrew Glaze was born in Nashville, Tennessee.
- 1907: Temple Emanu-El's Rabbi Milton Grafman was born in Washington D. C.
- 2014: Birmingham Post-Herald entertainment editor Emmett Weaver died.
- 2009: Birmingham Councilwoman Miriam Witherspoon died.
- 1992: Blues guitarist Johnny Shines died in Tuscaloosa.
- 1967: Former Birmingham City Schools superintendent Charles Glenn died in Birmingham.
- 1904: Railroad executive and Birmingham Steam Laundry founder Reinhard Wilda died.
- 1991: Birmingham Fire 31, Orlando Thunder 6 at the Citrus Bowl in Orlando, Florida.