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'''Twenty-second Street South''' ('''22nd Street South''') is a one-way [[north-south street]] in [[Birmingham]]'s [[Southside]] neighborhood, running south from the [[22nd Street Viaduct]] over the [[Railroad Reservation]] to [[Highland Avenue]], where it is interrupted by the [[Red Mountain Expressway]].
'''Twenty-second Street South''' ('''22nd Street South''') is a one-way [[north-south street]] in [[Birmingham]]'s [[Southside]] neighborhood, running south from the [[22nd Street Viaduct]] over the [[Railroad Reservation]] to [[Highland Avenue]], where it is interrupted by the [[Red Mountain Expressway]].


Another two-way section of 22nd Street South begins at [[Arlington Avenue]] and ends as it turns onto [[16th Avenue South]]. On the other side of [[Red Mountain]], there is a short two-way section of 22nd Street South in [[Mountain Brook]]'s [[English Village]], ending at [[21st Avenue South]].
A piece of [[22nd Street South]] serves as part of the offramp from the Expressway to Highland Avenue or to [[23rd Street South]], forming the southern edge of the [[Highland Park]] neighborhood. Another two-way section of 22nd Street South begins at [[Arlington Avenue]] and ends as it turns onto [[16th Avenue South]] in the [[Redmont Park]] neighborhood. On the other side of [[Red Mountain]], there is a short two-way section of 22nd Street South in [[Mountain Brook]]'s [[English Village]], ending at [[21st Avenue South]].
 
22nd Street South forms the border between the [[Five Points South neighborhood]] to the west and the [[Southside neighborhood]] to the east. It also forms the western edge of the [[National Register of Historic Places]]' [[Southside Historic District (NRHP)|Southside Historic District]] between [[4th Avenue South|4th]] and [[7th Avenue South]]. The first four blocks of 22nd Street South lie within the city's [[Historic Downtown Automotive District]], and the section from [[5th Alley South]] to [[7th Avenue South]] runs through the city's [[Southside Historic District]].
 
The 400 through 700 blocks of 22nd Street South are included in Birmingham's [[Midtown Commercial Revitalization District]], and the eastern edge of the [[City Action Partnership]]'s service area extending to [[5th Avenue South]].
 
The [[Red Mountain Railroad]] followed 22nd Street South up [[Red Mountain]] from [[15th Avenue South]] to [[Warwick Court]] on its way to [[Rosedale]] between [[1889]] and [[1893]]. In the 1940s, the street was one of the proposed routes for a [[Red Mountain Tunnel]].


== Notable locations ==
== Notable locations ==
{{Alphabetical locations}}
{{Alphabetical locations}}


=== [[Southside]] ===
=== [[Southside]] / [[Five Points South]] ===
* [[Railroad Reservation]]/[[22nd Street Viaduct]] (over [[Powell Avenue]]); road continues north as [[22nd Street North]])
* [[Railroad Reservation]]/[[22nd Street Viaduct]] (over [[Powell Avenue]]); road continues north as [[22nd Street North]])
** West side: Parking lot
** west side ([[Block 114 C]] & [[Block 114 F]]):
** East side: [[Williams-Blackstock Architects]] (2003-), former location of [[V & W Supply]], [[Nelson Manufacturing]] (built 1921/1925)
*** Parking lot
* [[1st Avenue South]]/[[Rotary Trail]] intersection ("[[The Cut]]" for [[Seaboard Air Line Railroad]])
** east side ([[Block 114 B]] & [[Block 114 G]]):
** West side:
*** [[Williams-Blackstock Architects]] (2003–), former location of [[V & W Supply]], [[Nelson Manufacturing]] (built 1921/1925)
*** 100: [[Brad Morton]] studio and residence, former location of [[Seaboard Saloon]] (built 1897)
 
*** 106: [[Fusoform]] concrete studio (2011-)
* [[1st Avenue South]] / [[Rotary Trail]] intersect ("[[The Cut]]" for [[Seaboard Air Line Railroad]]):
*** [[1st Alley South]]
** west side ([[Block 120]]):
*** 114: [[Mid-Alabama Chapter of the American Red Cross]], Birmingham-Jefferson office (2010-)
*** 100-104: [[Brad Morton]] studio and residence
*** 118: Parking lot (2010-), former location of [[The Screening Room]] theater (1982-2007)
**** 100-102: former location of saloon (1891), [[Seaboard Saloon]] (built 1897)
** East side:
**** 104: courtyard wall, former location of [[Wilson-Goodwin Tire Shop]] (1926) [[Bush Auto Body Co.]] (1941), [[Southside Auto Tim & Glass Co.]] (1964) [[Reeve Signs]] (1970)
*** 101: parking for [[Moxy]] talent and marketing
*** 106–110: one-story commercial building (built c. 1905), [[Magic City Signs]] (2019–), former location of [[Alabama Tire Exchange]] (1941), [[Beautyguard Manufacturing Co.]] (1964), [[Land of Was]] antiques (2007), [[Fusoform]] concrete studio (2011-)
*** [[1st Alley South]]
**** 106: former location of [[Birmingham Radiator Co.]] (1926)
***: [[Birmingham Wholesale Furniture]]
**** 110: former location of [[Samuel Vann]] auto repair (1926)
* [[2nd Avenue South]] intersection
*** 112–114: former location of [[Birmingham Fabricating Co.]] (1926), [[Hill Sales Inc.]] refrigerators (1941)
** West side
**** 114: [[Mid-Alabama Chapter of the American Red Cross]], Birmingham-Jefferson office (2010-), former location of [[Atlas Printing & Engraving Co.]] (1970), [[Keel Refinishing & Upholstery]] (2007)
*** 200:  
*** 116: former location of [[Thelma Jones]] laundry (1926)
** East side
*** 118–120: parking lot (2010-)
*** 201:  
**** 118: former location of [[Brocato Plumbing & Heating]] (1941), [[Modern Printing Co.]] (1970), [[Robert Lehman Studio]] furniture (2007)
* [[3rd Avenue South]] intersection
**** 120: former location of [[James Bouloukas]] restaurant (1941), [[The Screening Room]] theater (1982-2007)
** West side
*** 128: former location of [[Houser & Rogers]] saloon (1904)
*** 300:  
*** 130: former location of grocery / saloon (1891), [[P. J. Reed]] restaurant (1897)
** East side
** east side ([[Block 119]]:
*** 301:
*** 101-107: parking for [[Moxy]] talent and marketing. former used car lot for [[Cruse Crawford Manufacturing Co.]] (1941)
* [[4th Avenue South]] intersection
**** 101: former location of fruit stand (1891)
** West side
**** 103–107: former location of [[National Dry Cleaning Co.]] (1926)
*** 400:
*** 109: former location of [[T. L. Russell]] saloon (1904)
** East side
*** 115-131: [[Birmingham Wholesale Furniture]] (1970-)
*** 401:
 
* [[5th Avenue South]] intersection
* [[2nd Avenue South]] intersects:
** West side
** west side ([[Block 137]]):
*** 500:
*** 200–208: [[Raden building]] (built c. 1895 by [[C. Moritz Raden]])
** East side
**** 200: former location of [[Daniel Eyer]] grocery (1896–1899), [[Bower & Co.]] saloon (1904), [[Excelsior Bakery]] (1915–1918), [[Busy Bee Café]] (mid 1920s–early 1930s), [[Southside Paint & Supply Co.]] (1940–1950)
*** 501:
**** 202–206: former location of [[Refrigeration Sales & Service]] (1940), [[Maske & Kent Refrigeration Co.]] (1941)
* [[6th Avenue South]] intersection
***** 202: vacant (1926)
** West side
****** 202½: former location of [[Peter Stavros]] salesman (1926)
*** 600:
**** 204–208: former location of [[Walter White Auto Parts]] (1957–2007)
** East side
***** 204–206: former location of [[Hanna Motor Co.]] used car department (1926), electric shop (1957)
*** 601:  
****** 204: former location of [[Daniel Eyer]] saloon (1899)
* [[7th Avenue South]] intersection
******* 204½: former location of [[Mary Raden]] boarding house (1896), [[Louise Curtis]] boarding house (1899)
** West side
****** 206: former location of [[Birmingham Automotive Service]] (2007), [[Southern Radiator & Cooling]]
*** 7010:
***** 208: former location of [[Henderson Brewing Co.]] (1900), [[Francis Houghton]] auto repairs (1926), [[Federal-Mogul Service]] bearings (1941)
** East side
*** 210-230: [[Southern Armature Works]]
*** 701:
**** 210: former location of [[Keeley Service Station]] (1926), [[Albert T. Seals Auto Repair]] (1941–1970)
* [[University Boulevard]] intersection
**** 212–214: former location of [[Wengel Wilbern]]//[[Seagraves]]/[[The Flexible Co.]] ambulances & fire trucks (1941), [[Cather Brothers Printing & Publishing]] (1964–1970), [[Fulenwider Auto Supply]]
** [[Southtown Court]] and [[Southtown Court murals]]
***** 212: former location of [[New York Model Bakery]] (1887–1888), "ruins of fire" (1891), [[Midnight's Voice]] barcade (1974–1977)
* [[9th Avenue South]] intersection
**** 220: former location of [[Fariss-Armstrong Motor Co.]] (1941)
** Southtown Court
**** 224-230: former location of [[C. E. Reeves]] auto body & fender works (1941)
* 9th Court South intersection (west only)
***** 224: former location of [[Auto Electric & Carburetor Co.]] (1926)
**  
***** 226: former location of [[Charles Cram]] machine shop (1926)
* 9th Courth South (northeast)/[[10th Avenue South]] (west) intersection (road continues east as 10th Avenue)
***** 228–230: former location of [[Zylphia Freeney]] restaurant (1904), [[Frank Katz]] auto repairs (1926)
** east side ([[Block 138]]):
*** 201–215: [[The Battery]] (built as the [[BEBCO building]] in 1913, redeveloped 2018), former location of [[BEBCO]] (1913–), [[Cruse-Crawford Manufacturing Co.]] repair department (1926), [[Office Outfitters]] (1964)
**** 201–203: former location of grocery (1891),
**** 205–215: former location of "negro dwellings" (1891)
*** 215–231: [[J. F. Oates Building]] (built 1929), [[Birmingham School of Law]] (2013–), former location of [[J. Truett Payne Co.]] autos (1964–1970), [[Tom Williams Auto|Tom Williams Porsche/BMW]]
 
* [[3rd Avenue South]] intersects:
** west side ([[Block 146]]):
*** 300–310: [[DaVita Dialysis Clinic]], former location of [[Sherrill & Amos]] (1941), [[Jim Burke Nash]] (1945–1952), [[Chuck Milner Rambler]] (1964), [[Nelson-Brantley Glass Co.]] (1970), [[Franklin Automotive]], [[Platinum Imports]] (2007)
*** 312–330: parking lot
** east side ([[Block 145]]):
*** 301–311: former location of [[Birmingham Steam Bottling Works]] / [[Davis & Worcester]] (1886–c.1902)
**** 301: parking for [[Sweet Tea Restaurant]] (2011–), former used car lot for [[Fariss-Armstrong Motor Co.]] (1941)
*** 313–323: [[C & M Collision Center]] (2007–), former location of "negro dwellings" (1891), [[Merchants Cigar & Candy Co.]] wholesale sales (1941–1970)
*** 319–327: former location of residences (1926)
 
* [[4th Avenue South]] intersects:
** west side ([[Block 163]]):
*** 400–410: parking lot, former location of [[Birmingham Brewing Company (1889)|Birmingham Brewing Company]] (1889–1893), [[Alabama Brewing Company]] (1897–1907), [[Chuck Milner Rambler]] used cars (1964), [[Toyota Birmingham]] used cars (1970)
*** 416–430: [[Birmingham Cold Storage Warehouse]] (built 1916), former location of [[Schillinger Brewing Company]] (1884–1908)
** east side ([[Block 164]]):
*** 401–409: former location of "negro dwellings" (1891)
**** 401–407: [[Norton's Florist]] (2005–)
***** 401: former location of [[Chip Ellis Motorcars]]
***** 407: former location of [[Roy Bridges Motors]] (1964) [[Foreign Car City]] / [[Toyota Birmingham]] (1969-1970)
*** 411-431: former location of [[Birmingham Ice Factory]] (1887-1891), [[Birmingham Ice & Cold Storage Co.]] / [[City Ice Delivery Co.]] / [[National Coal & Coke Co.]] (1926)
 
* [[5th Avenue South]] intersects:
** west side ([[Block 172]]):
*** 500–528: [[Whitaker Building]] (built 2001), [[UA Health Services Foundation]]
**** 500–508: former location of [[Crawford Johnson & Co.]] / [[Birmingham Coca-Cola Bottling Co.]] (1926)
***** 500: former location of [[Birmingham Paper Co.]] (1941), [[Nifty Manufacturing Co.]] (1964)
**** 516–530: former location of [[Brownell Motors]] (1914-1983), [[W. F. Green Motors]] (1941)
***** 526–530: former location of [[Nifty Manufacturing Co.]] storage (1964)
** east side ([[Block 171]]):
*** 501: [[LIV on Fifth]] (2007-), former location of [[Tuck's Grocery Store]] (1907), [[American Standard Plumbing Warehouse]] (built 1924), [[Liberty National]] warehouse (-2007)
*** 503: former location of [[Standard Sanitary Manufacturing Co.]] (1926), [[Amstan Supply]] plumbing distributors (1964-1970)
*** 513–517: [[Iron City]] (2013-), former location of [[Richard King Automotive]]
*** 517–519: former location of [[Brammer Paint & Body Co.]] (1941)
**** 517: former location of [[Grayson Rose Automatic Transmission Co.]] (1964), [[Foreign Car City]] (1970)
*** 525: [[Iron City]] expansion (built 2019), former location of [[Speedy Print building]] (demolished 2018), [[Uncle Tom's Bar-B-Q]], [[Speedy Print]]
 
* [[6th Avenue South]] intersects:
** west side ([[Block 189]]):
*** 600: former location of [[Third Presbyterian Church]] (1891-1899)
*** 610–612: [[Harris Transfer Company]] warehouse (built 1916), [[Harris Transfer & Warehouse Co.]] / [[Ajax Sales Co.]] (1926), [[Storage Depot]] (2007), [[Fish Market]] restaurant (2007-), former location of [[2nd Presbyterian Church]] (1887)
*** 614–630: [[Taco Bell]]
** east side ([[Block 190]]):
*** 601–603: former location of grocery (1891)
**** 601: [[Alabama Civil Law Notary]], [[William J. Freeman]] attorney
**** 603: former location of ''[[Birmingham News]]'' branch office (1941)
*** 605: vacant (1926)
**** 605½: former location of [[Cotton Trading Co.]] (1926)
*** 607: former location of "shanty" (1891)
*** 611: former location of "shanty" (1891)
*** 613: former location of [[Ivy Discount Co.]] finance (1964)
*** 615: former location of "shanty" (1891)
*** 617–621: [[Third Presbyterian Church]] [[Bryan Educational Building]] (built 1960)
*** 627: [[Third Presbyterian Church]] (built 1902)
 
* [[7th Avenue South]] intersects:
** west side ([[Block 232]]):
*** 700–712: vacant lot (2019–)
**** 700: former location of [[Guaranty Acceptance Corp.]] (1964), [[Kao's Oriental Foods & Gifts]] (1975), [[Chai's Oriental Food Store]], [[Chai Market]] (demolished 2019)
**** 708: former location of [[Becksted Distributing Co.]] vacuum cleaners (1964)
**** 710: former location of ''[[The Examiner]]'' newspaper (1964), [[Capco Adjusters Inc.]] (1970), [[Rocky's Up 22nd]], [[Looking For A City Diner]], [[22nd Street Jazz Cafe]] ([[Al Rabiee|Al]] & [[Becky Rabiee]] 1991–2007)
**** 712: former location of [[Fuller & Crawford]] architects (1964), [[Fuller, Christian & Blake]] architects (1970)
*** 714–730: [[Johns Ridout Southside Chapel]]
** east side ([[Block 231]]):
*** 701–713: former location of [[Berthon's Cleaners]]
*** 715–731: parking lot for [[2208 University Boulevard]]
*** 725: former location of [[Jack's TV & Radio]] (1964), [[Alabama Restaurant Supply Co.]] (1970)
*** 727: former location of [[National Cleaners]] (1941), [[Waters Drive-In Cleaners]] (1964-1970)
 
* [[University Boulevard]] (8th Avenue South) intersects:
** west side ([[Block 760]]):
*** [[Baptist Church of the Covenant]] (1995-)
*** [[8th Court South]] intersects (west only)
*** [[Block 759]]
*** 828: former location of [[H. O. Powell]] dental laboratory (1964-1970)
*** 832: former location of [[Stead-Rockett Agency]] (1964), [[Stead Realty Co.]] / [[Walter Stead Insurance Agency]] (1970)
** east side ([[Block 744]]):
*** 811: former location of [[Brocato Plumbing & Heating Co.]] storage (1970)
*** [[Southern Research Institute]]
*** 819: former location of [[Brocato Plumbing & Heating Co.]] (1964-1970)
*** 823: former location of [[Nolan J. Wehby Plumbing & Heating Co.]] (1941)
*** 825: [[Southern Research Institute]], former location of [[Allen-Bradley Co.]] electric motors (1964-1970)
 
* [[9th Avenue South]] (formerly [[Quinlan Avenue]]) intersects:
** west side ([[Block 758]]):
*** 900: former location of [[G & H Management]]
*** 904: former location of [[Wagner Electric Sales Corp.]] (1970)
*** 912: former location of [[Ousler]] sandwiches (1926), [[Track Side Gas Station]] (1941), [[Allen Decorating Co.]] (1964-1970), [[Crow Studio]], [[Randal Crow]] photographer
*** 918: former location of [[Gulf Refining Co.]] gas station (1926), [[John B. Torbert]] filling station / [[Cahaba Valley Coal Co.]] (1941), [[South Highland School]] playground (1964-1970)
** east side ([[Block 745]]):
*** 901: former location of [[Gizmo Lounge]] (1960s-1980s)
*** 905: former location of [[Menendez Drapery Shop]] (1926), [[Dyer Electric Co.]] (1941-1970)
*** 909: former location of [[Ousler Sandwiches]] (1941-1970)
*** 911: former location of [[R. A. C. Smith]], plumber (1941)
*** 917: former location of [[Tom Dickinson & Co.]] auto repairs (1941), [[Imported Car Service & Body Shop]] (1970), [[Birmingham Bumper Service]] (1970)
 
* [[10th Avenue South]] (formerly [[Palmetto Avenue]]) intersects:
** west side ([[Block 757]]):
*** [[Brother Bryan Park]] (formerly [[Brother Bryan Park|Magnolia Park]])
** east side:
*** 929: [[2200 Magnolia Avenue]], former location of [[Birmingham Fire Station No. 3]], [[Hill Food Stores]] main bakery (1923), [[Family Laundry Service]] (1934), [[Ideal Heating & Refrigerating Co.]] (1941), [[Morris & Eckels]] laundry equipment (1960-1969), [[The Corner Stone]] head shop/coffee shop (1960s), [[Saunders Truck Leasing]] printing department (1970), [[Dick Jemison Gallery]] (1977) [[Birmingham Bumper Service]]
 
* [[Magnolia Avenue]] intersects:
** west side ([[Block 751]]):
*** 1000: [[Cory Watson Attorneys]], former location of [[Sycamore Storage Co.]] auto storage (1941)
*** 1016: former location of [[Commonwealth Life Insurance Co.]] (1964-1970)
*** 1018: former location of [[Freda Building Co.]] / [[G & H Home Builders]] / [[Merchants Home Builders]] / [[Von Dales Homes]] (1964), [[Gravlee Homes Inc.]] (1970)
*** 1020: former location of [[Johnson, Rast & Hays]] (1964), [[Donahue & Associates]] attorneys (2007)
*** 1022: former apartment building
*** 1028: former location of [[The Pauline Apartments]] (1964-1970)
*** 1030: former location of [[Sisters of Notre Dame]] convent (1941)
*** 1044: former location of [[Missionary Sisters of Verona]] convent (1970)
*** 1046: former location of [[Catholic Charities Bureau]] / [[Missionary Servants of the Most Blessed Trinity]] (1941)
*** [[Magnolia Alley]]
** east side ([[Block 750]]):
*** 1001-1013: [[Brownell Building]], [[Walter Schoel Engineering Company]], former location of [[Linde Air Products Co.]] (1941), [[Brownell Travel]] (1964-1970)
*** 1015: former location of [[James Bryan residence]] (1926)
*** [[Magnolia Alley]]
*** 1023: [[Gastroenterology-Children PC]] (2007), former location of [[Camp Apartments]] (1964-1970)
*** 1029: former location of [[John S. Odess]] & [[Andrew M. Brown]] physicians (1970), [[Southeastern Capital Corporation]] (2007)
*** 1033: [[Childcare Resources]] (2022–), former location of [[Harry Goldner]], [[Sam Kartus]], [[Myron Levin]], [[Robert M. May]], [[Arnold Royal]] & [[Ronald I. Goldberg]] physicians and [[Vernon Rosenthal]], dentist (1970), [[Canterbury Gardens Apartments]] (2007), [[St Vincent's Child Care Center]], [[Jefferson State Community College]] health care workforce training (2020–2022)
*** 1035: former apartment building
*** 1037: [[1037 22nd Street South]] office building
 
* [[11th Avenue South]] (west) /[[10th Court South]] (east) intersect:
** west side:
*** 1130<!--sic-->: [[Ridge Park]], former location of [[Rust Engineering]] (1970)
**** [[Brookwood Baptist Health]]
**** [[Sloss Real Estate]]
**** [[National Labor Relations Board]]
**** [[American Red Cross]]
**** [[Milo's Hamburgers]] offices
**** [[Shopping Center Group]]
* [[Ireland Way]] intersects (west only)
*** 1128: former location of [[Baptist Hospital Nurses Home]] (built 1945), [[L. Kianoff & Associates]] (demolished 2023)
*** 1140: former location of [[Highland Plaza]] shopping center (demolished 2023)
** east side:
*** 1101: [[Dr James Frank Building]] [[Southwestern Athletic Conference]] (2020–), former location of [[Pittman Financial Partners]] (–2020)
*** 1109: former location of [[Elements Inc.]] public relations (2007)
*** 1117: former location of [[James R. Garber]], [[John W. Simpson]] & [[James L. Seibold]] physicians (1941), [[John W. Simpson]] / [[Siebold & Batson]] physicians (1964)
*** 1125: [[Sycamore Court Apartments]] (1926-1970)
*** 1131: former location of [[Morgan A. Perry Jr]], [[James W. Underwood]], [[Malcolm Pigford]], [[Eldred Teague]] & [[George Zenger]], physicians, and [[Birmingham Radiological Group]] (1964)
*** [[Highland Shell]] gas station


* [[Highland Avenue]] intersects:
* street continues as on-ramp to [[Elton B. Stephens Expressway]] south ([[U.S. Highway 31]] south/[[U.S. Highway 280]] east)
** 1201: former location of [[The Maplewood]] apartments (1926)
** 1217: former location of [[Blessed Trinity Missionary Cenacle]] & [[Catholic Charities Bureau]] (1964)
** 1218: former location of [[The Vaughan]] apartments (1926)
** 1233: former apartment building
** 1236: [[The Tramont]] condominiums (built 2025)
** 1241: former location of [[Catholic Women's Club]] (1964-1970)
** 1248: former location of [[The Sycamore Manor]] apartments (1941-1970)
** 1251: former location of [[White-Douglas Home]] (1941), [[Ellen H. Douglas Home]] (1970)


* [[Arlington Avenue]] intersects:
** 1301: former location of [[The Maplewood]] apartments (1941-1970)
** 1312: [[Arlington School]] (2007)
** 1315: former apartment building (1964-1970)
** 1320: former location of [[Discovery Place]] children's museum (1981-1998)
** 1324-1326: former location of [[Vaughn Apartments]] (1941-1964), [[Arlington Plaza Apartments]] (1970)
** 1401: [[Saint Rose Academy]] (1998-), former location of [[Saint Rose Academy|St Rose of Lima School]] (1970), [[Discovery Place]] (-1998), [[Dominican Sisters]] (2007)
** 1412: former apartment building (1964-1970)
** 1424: former location of [[Youth For Christ of Greater Birmingham]] (1970)
*** [[Lee & Nancy Bruno Education Center]] (built 1993)
*** former site of [[Red Mountain Museum]] (1977-1998, demolished 2007)


[[Category:22nd Street South|*]]
[[Category:22nd Street South|*]]

Revision as of 09:31, 30 January 2024

Twenty-second Street South (22nd Street South) is a one-way north-south street in Birmingham's Southside neighborhood, running south from the 22nd Street Viaduct over the Railroad Reservation to Highland Avenue, where it is interrupted by the Red Mountain Expressway.

A piece of 22nd Street South serves as part of the offramp from the Expressway to Highland Avenue or to 23rd Street South, forming the southern edge of the Highland Park neighborhood. Another two-way section of 22nd Street South begins at Arlington Avenue and ends as it turns onto 16th Avenue South in the Redmont Park neighborhood. On the other side of Red Mountain, there is a short two-way section of 22nd Street South in Mountain Brook's English Village, ending at 21st Avenue South.

22nd Street South forms the border between the Five Points South neighborhood to the west and the Southside neighborhood to the east. It also forms the western edge of the National Register of Historic Places' Southside Historic District between 4th and 7th Avenue South. The first four blocks of 22nd Street South lie within the city's Historic Downtown Automotive District, and the section from 5th Alley South to 7th Avenue South runs through the city's Southside Historic District.

The 400 through 700 blocks of 22nd Street South are included in Birmingham's Midtown Commercial Revitalization District, and the eastern edge of the City Action Partnership's service area extending to 5th Avenue South.

The Red Mountain Railroad followed 22nd Street South up Red Mountain from 15th Avenue South to Warwick Court on its way to Rosedale between 1889 and 1893. In the 1940s, the street was one of the proposed routes for a Red Mountain Tunnel.

Notable locations

For an alphabetical list of locations, see the 22nd Street South category.

Southside / Five Points South