5th Avenue South

Fifth Avenue South (originally Avenue E) is a two-way, east-west avenue in Birmingham, one of the longest continuous avenues stretching across the city's south side. Portions of the street exist from North Titusville in the west to South East Lake in the east, but the main section runs from the Five Points South neighborhood all the way to Oak Ridge Park, becoming part of U.S. Highway 78 for a few blocks along its path.

Route

The beginning of 5th Avenue South is in the North Titusville neighborhood, west of downtown, at Center Street. It takes up from a short section of 5th Avenue Southwest that begins at Goldwire Street, about two blocks west of Center Street. The avenue ends at the intersection of 3rd Street and Omega Street.

In the Five Points South neighborhood, just east of the railroad tracks, the main portion of 5th Avenue South begins at 8th Street South. After passing under the raised portion of Interstate 65, in continues west through University of Alabama at Birmingham campus into the Southside neighborhood. There it passes under the Elton B. Stephens Expressway (U.S. Highways 31 and 280) and continues west into the Forest Park-South Avondale neighborhood.

As it enters East Avondale, 4th Avenue South, which is also U.S. Highway 78, merges into 5th Avenue at 45th Street. Thus 5th become Highway 78 for a few blocks, until the two split at 47th Street. Highway 78 continues east along Crestwood Boulevard while 5th turns more northeastward, forming the border between East Avondale and Crestwood North.

At the railroad tracks, the main road continues northeast as 1st Avenue South while 5th Avenue splits off more eastward to remain inside Crestwood North along the south side of the tracks. It continues into Oak Ridge Park before ending at Antwerp Avenue.

Another section begins in the East Lake neighborhood at Higdon Road where Hill Crest Behavioral Health Services is located, only to end at 71st Street. It begins again southwest of 75th Street and continues a short way into South East Lake before ending again at Vanderbilt Street. It resumes again one block northeast at 78th Street and ends at the entrance of Ossie Ware Mitchell Middle School at 81st Street. It resumes on the other side of the campus at 82nd Street before finally ending for good at 85th Street.

From 8th to 36th Street, the road provides two lanes of travel in each direction. It then becomes a two-lane road until meeting 4th Avenue and becoming Highway 78, where it is six lanes. North of Crestwood Boulevard, it is again four lanes until splitting off at the railroad tracks in Crestwood North. All other portions are two-lane, residential streets.

Notable locations

For an alphabetical list of locations, see the 5th Avenue South category.

North Titusville

• Center Street intersection (continues west as 5th Avenue Southwest)
  • 42: former location of Titusville Church of Christ (1953)
  • 55: former location of Eugene Smith restaurant (1953)
• 1st Street South intersection
  • 116: former location of George Motley clothes cleaner (1934)
  • 118: former location of Perry Owens clothes cleaner (1944), Bonita Ricks delicatessen (1953)
  • 200: former location of Patton & Clay (1920), Nabor's Sandwich Shop (Olemuel Nabors 1953)
• Omega Street intersection (road ends)

Five Points South neighborhood

• 8th Street South intersection (road begins)
  • 801: UAB internal operations and storage (2016-), former location of Rhodes-Carroll Furniture Co. warehouse (1926-1953), EBSCO Media
• 10th Street South intersection
  • north side (Block 278):
    • 1000: former location of Terry Showcase Co. (1926)
    • 1002: former location of Mann Brothers (1915)
    • 1010-1016: former location of Concordia Hall / Concordia Beneficial Society (1891-1953)
      • 1016: former location of Cocke & Lynch (1926)
    • 1018: former location of Penick & Ford Ltd insurance (1920), Penick & Ford warehouse (1934), Hanna Paint Co. (1953)
    • 1020-1032: former location of Knebel Engine Co. (1891), Southern Syrup Co. (1915)
      • 1032: former location of Phillips Boys (1926)
  • south side (Block 277):
    • 1001: former location of Douglass & Chewning (1904), Southern Foundry & Machine Co. (1909)
    • 1009-1015: former location of Abendroth & Fisher Manufacturing Co. (1891), Union Foundry & Machine Co. (1899-1904). Concrete Steel Co. fabricators (1920-1953)

• Interstate 65 underpass

• 11th Street South intersection
  • north side:
    • 1110: former location of Lewis Crews coal dealer (1944)
    • 1114-1116: former location of Birmingham Broom Manufacturing Co. (1915-1934), Birmingham Mop Manufacturing Co. (1934-1953)
  • south side:
    • 1101: UAB Intramural and Club Sport Field Complex (built 2018), former location of Colonial Coal Co. (1926), Colonial Coal & Coke Co. (1934), Charles Harvell auto repair (1944). Eleventh Street Garage (1953)
    • 1109-1113: former location of Birmingham Metal Products Co. warehouse (1915), Smallman-Brice Construction Co. (1920-1926), Ralph A. Smallman & Co. contractors (1934-1953)
    • 1115: former location of Arrow Transfer Co. (1926)

• 12th Street South intersection
  • former site of the Lane Teacher Building
  • 1201: former location of Rising Star Missionary Baptist Church (1899)
  • 1215: former location of Motor Freight Inc. (1953)

• 13th Street South intersection
  • north side:
    • 1300: site of proposed 7-story student apartment building (2022), former location of Quality Press (-2011)
  • south side:
    • 1313-1315: former location of Kirkpatrick Drilling Co. (1926-1934)
      • 1315: former location of Terry Showcase Co. (1920)
    • 1321: former location of Silas Coates (1926), Jefferson County Department of Human Resources building (demolished 2019)

• 14th Street South intersection
  • north side:
    • 1420: former location of Tutwiler Coal Co. (1915)
    • 1430: former location of Crane Co. shop (1934-1953)
  • south side:
    • 1401-1431: Jefferson County Department of Health Parking Deck, former location of Crawford-Vaughn Boiler & Locomotive Works (1926-1934)
      • 1401: former location of Camp Transfer & Warehouse Co. stables (1915-1920)
      • 1405: former location of Crawford Boiler & Locomotive Works (1915), Crawford-Vaughn Boiler & Locomotive Works / Universal Coal Washer Co. (1920)
      • 1431: former location of Birmingham Belt Railroad (1904-1920)

• 15th Street South intersection
  • north side (Block 157):
    • 1500-1530: Arlington Business Center
      • 1500: Cash4U car title loans, former location of Children's of Alabama facilities department (2011–2017)
      • 1506: Watts Realty (2011–2017)
      • 1510: Camp Smile-A-Mile offices (2011–2017)
      • 1512: Children's of Alabama Clinical Care Transport
      • 1516: Medical Resources, Inc. (2015–2017), former location of UAB Hospital critical care transport (2011)
      • 1526: Hanger Clinic (2016–), former location of Jefferson Clinic (2015)
      • 1520-1530: former location of Birmingham Tack Works (idled in 1891)
  • south side (Block 178):
    • 1501: McDonald's restaurant
    • 1519-1531: former location of Halle-Randolph Manufacturing Co. lumber and millwork (1904), Randolph Lumber Co. (1909), Ridgeway Paper Stock Co. (1920), Pan Am Coal Co. / Shelburne Sales Co. (1926), Summers Transfer & Storage Co. / Summers Bus & Transportation Co. (1934), R. G. Snider Concrete Co. (1953)
      • 1531: Captain D's restaurant

• 16th Street South intersection
  • north side (Block 158)
    • 1600: Children's Park Place, former location of Ziegler & Barrett Auto Parts (1957); former location of Nabers' Grove and William Nabers residence
    • former location of St John's Methodist Church (1885-)
    • 1616: former location of Standard Manufacturing Co. (1904)
  • south side (Block 177):
    • 1601-1631: Benjamin Russell Hospital for Children
      • 1601-1623: former location of Heidt-Nelson Coal & Lumber Co. (1904-1915), Heidt Coal & Lumber Co. (1920-1944)

• 17th Street South intersection (north only)
  • north side (Block 159):
    • 1700-1730: parking lot
      • 1700: former location of Birmingham Block Mills (1925), J. E. Penney storage (1926), Birmingham Baptist Church (1944), Abraham Baptist Church (1953)
      • 1712: former location of B. Vinson Coleman warehouse (1953)
      • 1716: former location of Cahaba Valley Coal Co. (1934), Franks Transfer Co. (1944), Murray Garage (1953)
      • 1724: former location of Carefree Rubber Co. store room (1944)
      • 1730: former location of Cumberland Presbyterian Church (1899)
  • south side (Block 176):
    • 1701-1731: Hazelrig-Salter Radiation Oncology Center and UAB Women and Infants Center
      • 1711: former location of T. B. Laycock Manufacturing Co. (1909), Young & Vann Supply Company warehouse (1915-1953)
      • 1731: former location of Ivy Leaf & Piper Coal Co. (1909-1920)

• 18th Street South intersection
  • north side (Block 160):
    • 1800-1818: Parking deck
      • 1800: former location of Samuel Burrano grocery (1934), Mishell Milton grocery (1944), Howard Branch Paint & Body Shop (1953), Automotive Friction Materials Co. (1970)
      • Suite 109: Moe's Southwest Grill
      • Suite 111: McAlister's Deli
      • Suite 115: Sitar Indian Cuisine (May 2019-), former location of Iberia Bank
      • 1818: former location of Peerless Laundry Co. (1926)
    • 1820: Courtyard by Marriott Birmingham Downtown at UAB
  • south side (Block 175)
    • 1801-1831: UAB North Pavilion
      • 1801: former location of J. H. Belser grocer (1899)

• 19th Street South intersection
  • north side (Block 161):
    • 1900-1908: Southside Station apartments, former location of Birmingham Goodwill Industries wood yard (1934), Dunham GMC Co. used trucks (1953)
    • 1910-1920: UAB 5th Avenue Parking Deck
      • 1916: former location of Bon-Ton Billiard Club (1925)
      • 1918: former location of Maggie Germany furnished rooms (1953)
    • 1922-1930 UAB Lot 55 parking lot, former location of the Parliament House hotel (1964–2007)
      • 1922-1926: former location of Arthur D. Snyder cabinet maker (1934)
        • 1922: former location of Afco Finance Co. parking lot (1953)
  • south side (Block 174):
    • 1901–1917: UAB School of Medicine Faculty Office Tower (built 2002)
      • 1901: former location of Peerless Ice Cream Co. (1934-1944), Hann the Rug Man cleaners (1953)
      • 1917: former location of Charles H. McCauley Associates (1960–1966), 1917 Clinic (1988–1993)
    • 1921: UAB Central Plant No. 3, former location of Arthur L. Hammack auto repairs / H. & S. Manufacturing Co. auto supplies (1934), Alabama Fixture Co. store fixtures (1944)

• 20th Street South intersection
  • north side (Block 162):
    • 2002-2024: former location of Drennen Motor Car Co. assembly plant (1944)
      • 2002-2004: former location of Masters Mattress Co. (1953)
      • 2008: former location of O. T. Dozier (1899-1904)
      • 2010-2016: former location of Drennen Motor Car Co. assembly plant (1926-1934), Drennen Motor Co. truck department (1953)
        • 2012: former location of Birmingham Mattress Co. (1904-1915), Steel By-Product Co. (1920)
      • 2016-2018: former location of Tate & Traylor Ford Doctors (1923)
        • 2016: Hotworx
        • 2018: former location of J. H. Houppert (1909), Pryor Motor Co. service department (1926)
      • 2020–2030: Weldon Martin Rubber building (built 1920)
  • south side:
    • 2001-2031: Kirklin Clinic (built 1992)
      • 2001-2017: former location of the Paul Hayne School (built 1886)
      • 2021-2031: former location of Crawford's Auto Shop (1926), Pryor Motor Co. service department (1934), Wheel Rim & Parts Co. (1953)

• 21st Street South (Richard Arrington Jr Boulevard South) intersection
  • north side (Block 163):
    • 2100-2130: former location of Schillinger's Brewing Co. (1891-1909)
      • 2100-2106: Alabama Organ Center annex
      • 2122-2130: Birmingham Cold Storage Warehouse (built 1916)
  • south side (Block 172):
    • 2101-2115: Kirklin Clinic Parking Deck
      • 2101: former location of Birmingham Paper Co. (1915)
      • 2111: former location of Furniture Warehouse Co. (1909), Charlie's Transfer Co. (1915-1926), Birmingham Paper Co. storage (1934)
        • 2111½: former location of New Process Cork Co. (1926)
    • 2117-2131: Whitaker Building (built 2001)

• 22nd Street South intersection
  • north side (Block 164):
  • 2200-2218: former location of City Ice Delivery Co. (1891-1952), Birmingham Ice Factory Co. (1891-1915), Birmingham Ice & Cold Storage Co. (1920-1953)
    • 2222: Happy Hounds, former location of Confederate Motors
  • south side (Block 171):
    • 2201: Liv on Fifth, former location of J. M. Tuck grocery (1899), F. W. Cook Brewing Co. (1915)
      • Suite 100: Clarus Consulting Group
    • 2203: former location of City Delivery Co. storeroom (1899), Lex Brewing Co. (1915)
    • 2207: former location of Harvey Furniture
    • 2211: former location of Anc-Co Preserving Co. / A. N. Chappell & Co. (1926), Birmingham Janitors Supply Co. (1944-1953)
    • 2213: former location of Birmingham Janitors Supply Co. (1926), Dixie Chemical Products Co. (1926-1953)
    • 2219: former location of William Beaven manufacturer's agent (1934-1944)
    • 2221-2231: Workplay

• 23rd Street South intersection
  • north side:
    • 2300-2320: former location of C. H. Feldner grocer (1899), Empire Fuel & Iron Co. (1915), Smith Coal Co. (1920), McLaughlin Coal Co. (1926), A. C. Coal & Coke Co. (1934), Paramount Fuel Co. (1944), Diamond Coal Yards (1953)
    • 2330: The Quest, former location of Brownell Auto Co. service department (1926)
  • south side:
    • 2301-2307: Sherwin-Williams
      • 2305: former location of A. Jackson barber (1899)
    • 2309-2315: Hires Root Beer building, Business Interiors (2014–), former location of Pepsi-Cola Bottling Co. (1944), Ted's Garage (2008–2014)
      • 2309-2311: former location of Pheonix Supply Co. (1926), Panter Tile & Marble Co. (1934), Furniture Distributors of Birmingham (1953)
      • 2313-2315: former location of George F. Wheelock & Co. (1926), Carmichael Tile Co. (1929), Birmingham Paper Stock Co. (1934)
    • 2317-2331: Estes Automotive Center
      • 2327: former location of Lewis J. Holmes auto repair (1934), Cleveland Manufacturing Co. auto bodies (1944-1953)
      • 2331: former location of Firestone Tire & Rubber Co. warehouse (1953)

Southside neighborhood

• 24th Street South intersects
  • north side:
    • 2400: former location of Day & Sachs contractors (1925–1934), Joseph G. Day & Sons contractors (1944)
    • 2408-2420 (called 2400): Bonds Brothers Building (built 1921), Goodwyn, Mills & Cawood architects, former location of Southern Furniture & Rug Co. wholesale (1953), Furniture Distributors of Birmingham (1957), 5th Avenue Antiques (-2019)
      • 2408-2410: former location of Dixie Awning Co. (1944)
      • 2412-2418: former location of Hinkle Bros. Co. roofers (1925-1944)
      • 2420 (addition): former location of Bonds Brothers Supply Company
  • south side:
    • former location of Cleveland Manufacturing Co. (1934)
    • 2409: former location of Domestic Laundry Co. (1909-1920), Greeson Auto Top Co. (1923)
    • 2431: former location of J. H. Bailey / J. L. Robinson physicians (1925)

• 25th Street South intersects
  • north side:
    • 2500: former location of Mary Wesley restaurant (1925), Joseph Cadenhead restaurant (1928)
    • 2502: former location of William Foster barber (1934)
    • 2508: Hertz
    • 2530: former location of Southern Roads Co. plant (1925), Bownman Transfer Co. (1953–1957)
  • south side:
    • 2503: Gulf Coast Rehab Equipment
    • 2505: Artistic Concept Florist
    • 2509: former location of Bauer & Co. (1904)
    • 2513: Tooter's Catering, former location of Fairchilds Coal Co. (1909)
    • 2523: Pattillo Balance & Hearing Center

• Elton B. Stephens Expressway underpass
  • north side:
    • 2600: former location of Assan Bohorfoush grocery (1920–1925), Biagio Rumore grocery (1934), Percy Hambra soft drinks / billiards (1944–1957)
    • 2608: Parking Enforcement Systems tow lot
    • 2612: Mt Olive Baptist Church (1957–)
    • 2626: former location of Atomic Welding Co. (1953–1957)
    • 2630: Weathertech Distributing Co. (2020-), former location of the ABC Co. (1915), Andrew Tedeski junk dealer (1925–1926), Lindsay Products Co. spices (1934), Mason & Dulion Co. sheet metal division (1953–1957)
  • south side:
    • 2603: former location of United Colored Printers (J. E. Perkins 1916–)
    • 2605–2607: former location of First Born Church of Living God (1944), New Liberty Missionary Baptist Church (1953–1957)
      • 2605: former location of Herbert Bosworth building materials (1934)
    • 2613: former location of Holt Manufacturing Co. office supplies (1953), Newell Equipment Co. (1957)
    • 2615: former location of Holt Manufacturing Co. inks & adhesives (1957)
    • 2617: Hutchinson Automotive
    • 2623: former location of Viola Austin furnished rooms (1957)
    • 2625: Red Mountain Rovers (2018), former location of Williams Machine & Welding

• 27th Street South intersects
  • 2700-2730 Absco Fireplace & Patio Absco Warehouse
    • 2722–2730: Artisan Flats (built 2022), former location Huston Biscuit Co. building (built 1902, demolished 2021), Huston Biscuit Co. (1887-1910), American Bakeries Co. (1910-1953), Bremmer Biscuit Co. (1957), ABSCO Fireplace & Patio warehouse (–2010s)
  • 2709: former location of Birmingham Stair Building & Hard Wood Works (1887), Industrial Furnace Construction Co. (1953–1957)
  • 2721: Trim Tab Brewing, former location of Trailmobile Inc. truck & trailer sales (1953–1957), Barber Motorsports Museum

• 28th Street South intersects
  • north side:
    • 2800: former location of Cherokee Mills flour (1925–1926), Birmingham Flour Co. (1934-1944), Southern Zonolite Co. (1953–1957)
    • 2806: former location of Cullman Produce Co. (1915)
    • 2822: former location of Salmon & Co. machine drillers / Samuel S. Williams power engineer (1953), East Alabama Excavating Co. (1957)
    • 2824: Warehouse building (built 1940s) Automatic Seafood and Oysters (2019-), former location of Automatic Sprinkler Corp. (1953–1957), Stegall Metal Industries, Aqua nightclub (2011-2014), Escape Birmingham (2015), Elevation nightclub, Xclusive Lounge, Club RIO, Redmont Distilling Co. (2016-2017)
  • south side:
    • 2801-2809: former location of Fairchild Coal Co. (1910), Pan-Am Coal Co. yards (1925), Mac-Wates Fuel Co. (1934-1957)
      • 2801-2805: Alabama Graphics & Engineering, former location of Alabama Coal Yard (1926)
      • 2809: Yarbrough Companies, former location of Robert McClure & Co. contractors / Myers & Jackson Electric Co. (1934)
    • 2831: former location of Southern Manufacturing Co. (1899-1904)

• 29th Street South intersects
  • north side:
    • 2900-2930: Lakeview Green (proposed), former location of W. C. Davis School (1949-1980s), Davis Center (1980s-2013, demolished 2018)
  • south side:
    • 2901: former location of Coleman & Samuels grocery (1934)
    • 2919: former location of Burt Brick & Cement Co. (1926)
    • 2923-2925: American Osment, former location of Feldner Grocery & Coal Co. (1909–1910), J. J. Overstreet & Son (1920), Arnold Supply Co. roofing materials (1934-1944), Hinkle Supply Co. roofing supplies (1953–1957)

• 30th Street South intersects
  • north side:
    • 3000: Alabama Stone Works, former location of Peerless-Alabama Co. plumbers' supplies (1934)
    • 3012: former location of Acme Storage & Transfer Co. (1934), Jack Cole Co. transfer (1944), Robert P. Stapp Inc. auto parts (1953–1957) / Southeastern Gunite Co. (1957)
  • south side:
    • 3001: former location of Sanders Truck Rental (1971)

• 31st Street South intersects
  • north side:
    • 3100: Partners Tax & Accounting / Hartline Investment Advisors (2016-), former location of Hamilton Parts & Equipment
    • 3120: former location of Transport Service Co. (1957)
  • south side:
    • 3101: Advance Auto Parts Store No. 8737 (2014–)
    • 3115: former location of Annie Jones soft drinks (1934)
    • 3117: former location of Crescent Wood Works Supply Co. (1953)
    • 3119–3129: Meeting Street Graphics
      • 3121: former location of Crescent Woodwork & Supply Co. warehouse (1957)

• 32nd Street South intersects
  • north side:
    • 3200-3208: former location of Alabama Oil Co. (1899-1910), Indian Refining Co. (1915-1920), General Oil Corp. (1925–1926), Hall Motor Express (1934), Cities Sale Corp. (1939), Silver Fleet Motor Express (1944), Murray Motor Transport (1953), West Bros Motor Express (1957)
    • 3224-3230: former location of Denegre Baked Enamel Remover Co. (1925–1926)
      • 3226-3230: former location of Steel Fabricating & Machinery Inc. (1944-1957)
        • 3230: former location of Windham Bros Construction Co. (1910)
  • south side:
    • 3201: Tsitalia Imports, former location of A. A. Polis boarding house (1899)
    • 3229: former location of Greil Bowman ice & coal (1953), Louis Bowman ice & coal (1957)

• 33rd Street South intersects
  • north side:
    • 3300: American Pipe & Supply, former location of The Texas Co. plant (1920-1944), Alabama Highway Express (1953–1957)
  • south side:
    • 3301-3307: former location of Salvation Army Rescue Home (1909-1926)
    • 3309: former location of Salvation Army Rescue Home annex (1925–1926)
    • 3317: Kendell Electric, former location of Roden Electrical Supply Company

• 34th Street South intersects
  • north side:
    • 3400–3436: Mayer Electric Supply
  • south side:
    • 3401: Bodega on Fifth, former location of The Arbor (1980-2007), Elegant Earth at the Arbor (2007-2019)
    • 3409: Nicole Roby Designs
    • 3413: Grassroots Wine Wholesalers
    • 3421: Lighting Partnership
    • 3425: Consumer Financial Education Foundation of America

• 35th Street South intersects
  • north side:
    • 3500: Birmingham Luxury Motors Service Center, former site of Williamson-Willey Pontiac Plaza, Ethan Hunt Auto
  • south side:
    • 3501–3541: Alabama Workforce Training Center / Academy of Craft Training

• 36th Street South intersects
  • north side:
    • 3600: DME Services
    • 3608: former location of T.J.'s BBQ
    • 3616: Deft Dynamics / Tocaro Blue (2023–), former location of Skyline Exhibits & Graphics (2008), R.O.S.S. Recovery Center (2021–2023)
    • 3624: Avondale Animal Hospital, former location of Birmingham Limb & Brace
    • 3626: The Pawms Pet Resort
  • south side:
    • 3601: Davis Wholesale Florist, former location of Jackson Hardware Supply Co. (1969)
    • 3611: former location of Chapman Gates contractor (1934)
    • 3615: Sullivan Service Co.
    • 3617: RuffCraft (2021–), former location of Charles F. Wheelock & Associates, Triple 2 Tattoo (2017–2019)
    • 3619: former location of George H. Clark upholstering (1953)
    • 3621: House Plant Collective, former location of Grand York Rite of Alabama offices (1974–1979), GBM Office Systems (1981–1992)
    • 3625: Sound of Birmingham
    • 3629–3631: United Trophy & Specialties (2020–), former location of Lane Energy Systems
      • 3631: former location of M. W. Kirby grocery (1925), Lovic Waddell grocery (1934), Riddle's Creamery grocery (Charles Riddle 1953), Gladney Creamery (Byron Gladney 1957)

Forest Park-South Avondale

• 37th Street South intersection
  • north side:
    • 3700: Jeffcoat Building (built 1994), B & A Warehouse on 5th (2007–), former location of Jeffcoat & Associates, Vet-Co Inc.
    • 3712–3716: European Kitchens of Alabama (Loay Ali, 2021–), former location of E Tech Communications (2011–)
    • 3718–3728: vacant, proposed location of townhomes
    • 3732: Fusion Apartments, formerly Emerald Terrace Apartments (–2011)
  • south side:
    • 3701–3707: former location of Church & Stagg Printing (2008–2011)
      • 3703: Printing Place / RPA Inc. / Pete Pritchard architect
      • 3705: former location of Lillian Sullivan beauty shop (1934)
    • 3707–3727: Cottages on Fifth (built 2018)
    • 3731: one-story fieldstone residence

• 38th Street South intersection
  • 3800: Fifth Avenue Apartments
  • 3826: former location of Adeeb Saab manufacturer's agent (1953)
  • 3833: Avondale United Methodist Church (built 1922-1925)

• 39th Street South intersection (north only)
  • 3900: residence (built c. 1890)
  • 3906: residence (built c. 1890)
  • 3910: residence (built c. 1890)
  • 3916: residence (built c. 1925)
  • 3924: apartment building (built c. 1970)
  • 3926: apartment building (built c. 1970)

• 40th Street South intersection (south only)
  • north side:
    • 4032: Pyle's Clock Shop
    • 4036: Avondale Marble Works building, Parkside on Fifth (Tim Burt 2022–), former location of Avondale Marble Works (1915-1920), Avondale Marble & Granite Works (1926-1934), Parkside Home & Garden (Tim Burt 2000–2008), Parkside Cafe (Michael Dykes, Neil Kirkpatrick 2009–2021)
    • 4038-4040: Ferus on 41st (2021–) / The Marble Ring, former location of Dominick Lusco (1909), K. B. Efthoxios (1920), –Ford Graves (1926), Mary Falkner beauty shop (1934-1944), P. Adale Beauty Shop (1953), A & P, Number One Barbecue, Trés Taylor's studio, Fancy's on 5th (2016–2020), Hot Diggity Dogs (2016-2020), Chef Peoples Cafe (2021), former site of
  • south side:
  • 4001: Avondale Regional Library

• 41st Street South intersection (north only)
  • north side:
    • 4100: Munchies Food Store / Taco Morro Loco, former location of Ellis Grey filling station (1934), Johnson & English Service Station / Auto Carburetor & Ignition Co. (1953), Avondale Grill
    • 4116: former location of His House Christian commune
  • south side:
    • 4101: Avondale Park

• 42nd Street South intersection (south only)
  • 4210: former location of Avondale First Methodist Church (1909), Avondale Methodist Episcopal Church (1915-1920)
  • 4243: former location of Meehan Flag & Decorating (Daisy Meehan 1953)
  • 4246: Aletheia House, former location of the Avonwood Rest Home
  • 4266: residence (built c. 1912)

• 43rd Street South intersection
  • 4300–4308: AvonDwell apartments (built 2020)
  • 4328: former location of James Tidwell contractor (1934)
• 44th Street South intersection
  • 4413: Birmingham Friends Meeting / Burdock Book Collective
  • 4416: former location of John R. Ball interior decorator (1934)
  • 4439: Birmingham Fire Station No. 10/22
  • 4449: former location of E. H. Abts & Son heating & sheet metal work (1953)
  • 4453: former location of Avonwood Service Station (1934), Flowers Servicenter service station (1953)
• 45th Street South intersection, street merges with 4th Avenue South

Forest Park-South Avondale/East Avondale

• 45th Street/4th Avenue South intersection (becomes U.S. Highway 78 from west)
  • 4500: Continental Gin Co. manufacturers (1944-1953)
  • 4501: former location of Avonwood Drug Co. (1926-1944), Avonwood Flower Shop (1934), Crouch-Holley Drug Co. (1953)
  • 4503: Accounting & Business Consultants, former location of C & M Grocery Co. (1934), N & W Food Store (1944), Food Lane Superette (1953)
    • 4503 rear: former location of McDonald Cafe (1927)
  • 4505-4507: former location of Hill Grocery Co. (1944-1953)
    • 4505: former location of Great A & P Tea Co. (1926), Hill Grocery Co. (1926-1934)
    • 4507: former location of Avonwood Cafe (1926), Clifford George barber (1934)
  • 4509: former location of Avonwood Cleaning & Dyeing Company / Avonwood Barber Shop (1926)
  • 4511: former location of Great A & P Tea Co. (1934), C & M Grocery Co. (1944-1953)
  • 4513: former location of Thomas Floyd bakery (1934), Bullion's Cafe (1944), Avonwood Grill (1953), Seasick Records
  • 4515-4531: Southern Skin Divers Supply
    • 4517: former location of Standard Oil Co. gas station (1934), Homer Poor filling station (1944-1953)

• 46th Street South intersection
  • north side:
    • 4601: Harris Auto Sales
    • 4603-4607: former location of Avonwood Dry Cleaning Co. (1934-1944), Avonwood Cleaners (1953)
    • 4625: former location of Avonwood Service Station
  • south side:
    • 4600: Dollar General, former location of Sam Sciara coal dealer (1934), Nomtae
    • 4612: former location of JoJo's Gun and Pawn
    • 4650: former location of Mt Calvary Baptist Church (1934)

East Avondale/Crestwood South

• 47th Street South intersection
  • 4704-4712: former location of Avonwood Hardware & Variety Store (1953)
    • 4710: World Class Auto Repair
  • 4726: former location of Richard Zarzour grocery (1934), Louis Rookis grocery (1944), Economy Market (1953), Club 4726 (Gracie Shedrich 1961–1970)
  • 4730: former location of Grand Avenue Market & Grocery (Anthony Scozzaro 1944), James Sawyer grocery (1953)
• Crestwood Boulevard intersection (Highway 78 follows Crestwood to east)

East Avondale/Crestwood North

(formerly Grand Avenue)

• 48th Street South intersects
  • north side:
    • 4814: FunktionArt, former location of H & H Outboard Service Station (1964-1970), Amps Cycle (2007)
    • 4830: former location of Grand Avenue Service Station (1934-1953), Baumgardner Service Station (1964), Bill's Texaco (1970)
  • south side:
    • 4801: former location of Park & Widener Real Estate (2007)
    • 4807: Birmingham Trophy Shop (2007-)
    • 4829: former location of Hill Grocery Co. (1926)
    • 4831-4839: Beauty Shock salon (2015-), former location of Birmingham Electric & Belt Railway substation (1915), Alabama Plating Co. (1934), Birmingham Helpy-Selfy Laundry (1953), Mack's 1-Hour Cleaners (1964), Ware Heating & Air (1970), K P Studios photographers (2007)

• 49th Street South intersects
  • north side:
    • 4900: Alabama Construction Supply (2007-), former location of Crestwood Market (1953)
    • 4908: former location of Steel City Electric Co. contractors (1964-1970)
    • 4916: former location of AAA Plumbing & Heating Co. (1964)
    • 4920: former location of Delma Nichols barber (1934), Arthur Franklin barber (1944), Bacon's Barber Shop (1953)
    • 4922: former location of Murray's Pharmacy (1934), Grand Avenue Beauty Salon (1941), Radio Electronic Engineering Co. (1953)
    • 4924: former location of LaDame Cleaners (1941), Howard's Cleaners (1944), Employee Furniture & Buying Co. (1953)
    • 4926: former location of Southern Roofing & Heating Co. (1934), Barclift Feed & Coal (1941), Lance Inc. storage (1944-1953), Carl Jones Auto Parts (2007)
  • south side:
    • 4909: Manitou Supply (2017-), former location of Peerless Gas & Appliance Co. (1953), Electric Tool Co. (1953-1964), Advance Glass Co. cutting room (1970)
    • 4911: The Jaybird (September 2017-), former location of The Beauty Box beauty shop (1964), Jean's Beauty Salon (1970)
    • 4913-4915: former location of Best Food Market (1941)
      • 4913: former location of Hill Grocery Co. (1934), Grand Avenue Market (1953)
      • 4915: Bib & Tucker Sew-Op, former location of Best Food Market (1934), A & M Hardware Co. (1953), Advance Glass Co. (1964-1970), Brezina Furniture Repair Service (2007), Grand Avenue Market (2012)
    • 4917: Brezina Refinishing, former location of Wofford Oil Co. filling station (1934), Better Service Station (1941), Barker Bros. Service Station (1953-1970), Carl Jones Auto Parts machine shop (2008)
    • 4933: former location of Fren-Le Inn restaurant (Mrs L. Kelly 1941), Friendly Inn ([A. H. Lumpkin]] 1942), Browning's Cafe (Arthur Browning 1953), Dora's Cafeteria (1964-1970)
    • 4933 1/2 St Mark Missionary Baptist Church (2005)
    • 4937: Living Waters Ministries Church of God in Christ (-2019-), former location of All Nations Worship Center (2007-)

• 50th Street South intersects
  • north side:
    • 5000: CMC Steel Alabama
    • 5004: Cooper Construction (2007-)
    • 5006: former location of Continental Budget Corp. & Ashcraft Distributors (1964-1970)
    • 5016: former location of Ace Neon Sign Co. (1964-1970)
  • south side:
    • 5005: former location of Grand Apartments (1970)
    • 5009: former location of Woodlawn Highlands Baptist Church annex (1953)
    • 5013-5015: former location of P & L Grocery (1941-1944)
      • 5015: former location of Victor Graffo Market grocery (1953), Jerrell Upholstery Co. (1964)
    • 5017: former location of Alley's Drug Store (1941-1944), Patten's Sundries (1953), American Electronic Products Company (1964), Rose's Automotive School (1970)

• 51st Street South intersects
  • 5101: former location of The Birmingham News branch (1964-1970)
  • 5118: former location of Paul's Cleaners & Laundry (1953), Faucett Brady Steel erection yard (1970)
  • 5120: former location of Alley's Drug Store (1934), Superior Venetian Blind Co. (1941), LaDame Cleaners / Grand Avenue Baptist Church (1944), George's Place restaurant (1949), Barney's Place (Barney Coats 1953-1958), Barney's Drive-In (1964-1970), the Tool Box nightclub, Phoenix Cabaret nightclub (2007), destroyed by fire October 2016
  • 5134: former location of Best Gas & Oil Co. filling station (1934)
  • 5141: former location of Woodlawn Beauty Service (1934)

• 52nd Street South intersects
• Seaboard Railway crosses over street
  • 5209: former location of Sims Auto Repair Shop (1944-1964), Woodlawn Ornamental Arts (1970)
  • 5212: former location of Emens Cleaners (1953-1964)
  • 5216: former location of AAA Electric Co. contractors (1964)
  • 5217: Bhate Geosciences (2007-), former location of George Alexander general contractor (1944), Custom Craft Home Improvement Co. (1970)
  • 5220: former location of Guin Co. plumbers (1964-1970)
  • 5229: former location of Perfection Tackle Co. (1964-1970)
  • 5232 rear: former location of Hawkins Garage auto repair (1964)
  • 5241: former location of Hill Grocery Co. (1934)
  • 5243-5245: former location of Francis Woods grocery (1944) A. W. Hooper Co. machinery (1953-1964), Hooper Equipment Co. (1970)

• 53rd Street South intersects
  • 5302: former location of J. D. Moore Flooring Co. (1970)
  • 5305: former location of Crestwood Court Apartments (1953-1970)
  • 5312: former location of Birmingham Trophy Shop
  • 5313: former location of Crestwood Nursery School (1964-1970)
  • 5316: former location of Birmingham Trophy Shop (1938)
  • 5331: former location of Young Men's Home (1926)

• 54th Street South intersects
  • 5400-5450: former location of Woodlawn Union Station (1915-1941)
    • 5400 rear: former location of Watkins Printing Co. (1964-1970)
  • 5401: former location of Hill Grocery Co. (1926)
  • 5437: Groveland Baptist Church (2007-)

• 5th Avenue South intersects
• 54th Place South intersects (south only)
  • Residential
  • 5929: former location of Southside Wholesale Electric (2007)
• 62nd Street South intersection (south only)

Oak Ridge Park

• 62nd Street South intersection (south only)
  • 6427: former location of Jesse's Confectionary (1953)
• Antwerp Avenue (road ends)

East Lake neighborhood

• Higdon Road intersection (road begins)
  • 6869: Hill Crest Behavioral Health Services, Higdon Hill School
  • 6901: former location of Samuel McAlister interior decorator (1934)
  • 7000: former location of Crest Hill Sanatorium (1926-1934)
• 71st Street South intersection (south only; road ends)
• Road begins
• 75th Street South intersection
  • 7631: First Baptist Church of East Lake (1946)
• Oporto-Madrid Boulevard intersection

South East Lake

• Oporto-Madrid Boulevard intersection
  • 7631: former location of East Lake Baptist Church (1926-1953)
• Vanderbilt Street intersection (south only, road ends)
  • 7720: former location of Sigma Phi Epsilon house (1934)
  • 7725: former location of Pi Kappa Phi house (1934)
• 78th Street South intersection (road begins)
  • 7921: Herman Brown Ministries
• 81st Street South intersection (road ends)
  • Ossie Ware Mitchell Middle School
• 82nd Street South intersection (road begins)
  • 8336: former location of Willis Glenn contractor (1934)
  • 8439: former location of Margaret Kincaid beauty shop (1934)
• 85th Street South intersection (road ends)